VivoCAR™ Anti-MUC1 (1B2) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX50)

Name: VivoCAR™ Anti-MUC1 (1B2) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX50
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-MUC1 (1B2) h(CD28-41BB-CD3z) CAR circRNA is specifically designed to overcome the physical barriers of the glycocalyx in adenocarcinomas. The 1B2 clone is vital for its high-affinity binding to the peptide core of MUC1, enabling in vivo generated CAR-T cells to penetrate the dense mucin layer of solid tumors. By utilizing the non-integrating circRNA platform, this product offers a transient but high-intensity therapeutic pulse, allowing researchers to study immediate tumor debulking while ensuring that CAR expression naturally tapers off to prevent long-term impact on healthy secretory tissues.

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Target Information

Target
MUC1

Common Name
MUC1

Alternative Names
ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X/ZD, PEM, PEMT, PUM, MUC1

Full Name
Mucin 1, Cell Surface Associated

Introduction
MUC1 is a transmembrane glycoprotein overexpressed and aberrantly hypo-glycosylated in many carcinomas (e.g., breast, pancreatic, ovarian). This aberrant expression exposes normally masked peptide epitopes, making it a highly validated and accessible target for CAR-T cell therapy against epithelial tumors.

Targeting Diseases
Breast Cancer, Pancreatic Cancer, Ovarian Cancer, Colon Cancer, Lung Cancer

UniProt ID
P15941

Gene ID
4582

Target Species
Human

Antibody Clone
1B2

scFv-Host Species
Mouse

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.