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Anti-Peptide FKA T cell receptor (YAe62β), pCDTCR1 (TCR-YC0908)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

YAe62β mice allow for the isolation of IAb-3K reactive TCRs carrying the identical TCRβ chain sequence which develop in either conventional mice and are dependent upon MHC class II proteins for positive selection, or develop in MHC class II-deficient mice and are dependent upon MHC class I or non-classical MHC class I ligands for positive selection.

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Details

  • Target
  • Peptide FKA
  • Epitope
  • FKAQKAKANKAVD
  • Format
  • Non-Modified TCR
  • Allele
  • H2-IAb
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • YAe62β
  • Host Species
  • Mouse

Target

  • Introduction
  • T cell antigen receptors (TCR) recognize ligands displayed on classical Major Histocompatibility Complex (MHC), non-classical MHC and MHC-like proteins. Classical MHC proteins are the most polymorphic genes in humans. Within a population, MHC allele diversity greatly limits the ability of pathogens to escape immune responses. However, the diversity of MHC creates a unique problem for generating host-MHC restricted mature T cell repertoires. Prior to selection, TCR rearrangement has to generate a collection of TCRs which, in aggregate, have the ability to recognize any of the possible MHC classes and alleles present within a species. After selection, individual TCRs must be MHC class specific, allowing a division of labor between MHC class II-reactive helper T cells and MHC class I-reactive cytotoxic T cells.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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