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Anti-VgaB T cell receptor (Ob.1A12), pCDTCR1 (TCR-YC1324)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-VgaB T cell receptor (TCR) is constructed for the engineering of T cell to target pristinamycin resistance protein VgaB (VLARLHFYRNDVHKE) restricted by HLA-DRB1*15:01. The T cells are genetically modified through transduction with a lentiviral vector expressing VgaB-specific T cell receptor.

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Details

  • Target
  • VgaB
  • Target Species
  • Staphylococcus aureus
  • Epitope
  • VLARLHFYRNDVHKE
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-DRB1*15:01
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • Ob.1A12
  • Host Species
  • Human

Target

  • Introduction
  • The Staphylococcus aureus plasmid gene, vgaB, conferring resistance to streptogramin (SgA) and related compounds (PIIA, virginiamycin M, mikamycin A, synergistin A, Dalfopristin) was cloned and sequenced. This gene potentially encodes a 552-aa protein, VgaB, of 61,327 Da, which exhibits a significant similarity with the ATP-binding domains of numerous proteins. VgaB has two ATP-binding domains containing each of the A and the B motifs, but does not include TM hydrophobic domains. The 155-amino-acid sequence between the two ATP-binding domains of VgaB is richer in Glu than the rest of the protein. The vgaB gene was found in 21 of the 52 SgA(R) and independent wt staphylococci investigated. In each of the 21 staphylococci, vgaB was carried on a plasmid of 50-90 kb also harboring the vatB gene encoding an acetyltransferase inactivating SgA. In all plasmids, vgaB and vatB have the same relative positions.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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