Creative Biolabs offers a wide range of high-quality plain liposome products in different formulations. All the products are prepared by our advanced LipoDrive™ technology platform using the highest quality lipids provided by leading global ingredient suppliers. The particle size of liposomes is ranged from 50nm to micron level with high batch-to-batch consistency and homogeneity. You can choose any of the formulations, PEGylated or non-PEGylated according to your experimental needs.
Liposomes have received extensive attention and are widely investigated as a promising drug carrier. They can be functionalized through the incorporation of different small molecules, surface modifications, and valent coupling. Plain liposomes have the simplest lipid composition and function and therefore be used to study lipid membrane-protein interactions, in vivo studies of liposomes, and encapsulation of hydrophobic drugs. Liposomes made from phosphatidylserine (PS) are negatively charged vesicles, which can be used to mimic cell membranes. Positively or neutrally charged liposomes are also available, mainly consisting of DOTAP and Phosphatidylcholine (PC) respectively. Additionally, all the plain liposome products can be loaded with hydrophobic drugs through hydrophobic interaction or used as control formulations for drug-loaded liposomes. If you are looking for any other liposome products, please see our liposome development service, every parameter of the liposome is highly customizable.
As a leader in the field of liposome development, Creative Biolabs has served clients all over the world. Each batch of our product is freshly manufactured with the best quality and stability. Feel free to contact us for any technical support about our products.
Protective effect of saccharides on freeze-dried liposomes encapsulating drug
Author: Guimarães, Diana, et al.
This study investigated the protective effects of adding different saccharides to liposomes during the freeze-drying process. Researchers added five saccharides at varying concentrations to the liposomes: trehalose, lactose, glucose, mannitol, and sucrose. Subsequently, the size and polymer dispersity index (PDI) of liposomes after the freeze-drying-rehydration cycle were measured to monitor the aggregation and fusion of liposomes in each group during the freeze-drying process. The results showed that, compared to plain liposomes, liposomes with saccharides could prevent aggregation and fusion in a concentration-dependent manner, thereby maintaining the integrity of freeze-dried liposomes. Among them, the protective effect of sucrose was most significant, making it a promising method for liposome storage. This highlights the importance of plain liposomes as controls, providing a baseline for studying the protective effect of saccharides as cryoprotectants on liposomes.
Fig.1 The particle size and PDI of each group of liposomes.1,2
References
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Cat | Product name | Lipid Composition | Applications | Data sheet | MSDS | Inquiry |
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LDLY-0123-LY76 | 18:1 Diether PC:Chol Liposomes | 18:1 Diether PC Cholesterol |
Control liposomes, Membrane biology |
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Inquiry |
LDLY-0123-LY77 | Brain PC Liposomes | Brain PC | Control liposomes, Membrane biology |
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Inquiry |
LDLY-0123-LY78 | Egg PC Liposomes | Egg PC | Control liposomes, Membrane biology |
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Inquiry |
LDLY-0123-LY79 | Heart PC Liposomes | Heart PC | Control liposomes, Membrane biology |
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Inquiry |
LDLY-0123-LY80 | Liver PC Liposomes | Liver PC | Control liposomes, Membrane biology |
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Inquiry |
LDLY-0123-LY81 | Soy PC Liposomes | Soy PC | Control liposomes, Membrane biology |
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Inquiry |
LDLY-0123-LY82 | Brain PC:Chol Liposomes | Brain PC Cholesterol |
Control liposomes, Membrane biology |
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Inquiry |
LDLY-0123-LY83 | Egg PC:Chol Liposomes | Egg PC Cholesterol |
Control liposomes, Membrane biology |
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Inquiry |
LDLY-0123-LY84 | Heart PC:Chol Liposomes | Heart PC Cholesterol |
Control liposomes, Membrane biology |
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Inquiry |
LDLY-0123-LY85 | Liver PC:Chol Liposomes | Liver PC Cholesterol |
Control liposomes, Membrane biology |
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Inquiry |
LDLY-0123-LY86 | Soy PC:Chol Liposomes | Soy PC Cholesterol |
Control liposomes, Membrane biology |
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Inquiry |
LDLY-0123-LY87 | Hydro Egg PC Liposomes | Hydrogenated Egg PC | Control liposomes, Membrane biology |
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LDLY-0123-LY88 | Hydrogenated Soy PC Liposomes | HSPC | Control liposomes, Membrane biology |
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Inquiry |
LDLY-0123-LY89 | Hydro Egg PC:Chol Liposomes | Hydrogenated Egg PC Cholesterol |
Control liposomes, Membrane biology |
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Inquiry |
LDLY-0123-LY90 | Hydrogenated Soy PC:Chol Liposomes | HSPC Cholesterol |
Control liposomes, Membrane biology |
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Inquiry |