Pharmacodynamic Study Services

Importance of Pharmacodynamic Study

Pharmacodynamics (PD) is the study of drugs' physiological and biochemical effects, as well as their impact on organisms. PD study is essential for understanding the pharmacological activities of drugs in the formulation development process. This field is typically divided into in vitro and in vivo studies. The combination of in vitro and in vivo studies provides a comprehensive and objective assessment of pharmacological activities and properties, thereby advancing drug development. With our decades of experience in PD, Creative Biolabs has established a diverse model library (in vivo and/or in vitro) for your selection. Additionally, to assist you with the analysis and interpretation of your data, we offer standardized downstream analysis services.

Fig.1 In vivo and in vitro pharmacological study in Creative Biolabs.

In Vitro Models

Cell models allow for microscopic investigation of disease pathophysiology and drug effects. They possess characteristics of simplicity, speed, and convenience for assessing efficacy and performance. Creative Biolabs can provide you with cell models specially designed for evaluating the antibacterial, anticancer, antiviral, anti-inflammatory, and other properties of nanoparticles. It provides a significant contribution to understanding the impacts of nanoparticles on various cells and their mechanisms of action.

In Vivo Models

The validation of the effectiveness of nanoparticles ultimately requires in vivo studies, no matter how complex the in vitro models are. Animal models, which are physiologically similar to humans and have shorter disease courses, allow for rapid and in-depth study of the potential disease mechanisms and specific signaling pathways in human diseases. The selection of appropriate animal models is key to objectively evaluating drug efficacy, often opting for disease animal models relevant to the target indication. Creative Biolabs' extensive animal model repository can provide researchers worldwide with high-quality and reliable animal models, including xenograft, neurological disease, cardiovascular disease, and more.

Pharmacodynamic Analysis

Creative Biolabs offers analytical services to provide you with detailed information on the effectiveness of nanoparticles in drug delivery.

• Symptom reversal: Changes in protein and enzyme levels or animal behavior after administration serve as indicators of the efficacy of nanoparticles in drug delivery.
• Organ analysis: Microscopy techniques (fluorescent or confocal microscopy) are used to investigate the distribution of nanoparticles after drug administration.
• DNA/RNA extraction: DNA and RNA expression in tissue samples is used to evaluate nanoparticle biological dispersion.
• Protein extraction: Western blotting (WB) was used to determine the relative amount and kind of protein.
• Blood analysis: Whole blood and plasma tests are used to determine the presence of drugs.

Why Choose Us?

• Research background in multiple fields such as oncology, immunology, neurology, hematology, dermatology, and cardiovascular.
• Diverse animal/cell models.
• Personalized multi-dimensional pharmacodynamic evaluation system.
• Objective, sensitive, quantitative detection methods.
• Cost-effective.

Drawing upon decades of expertise in pharmacological studies and leveraging our advanced technology platform, Creative Biolabs offers a diverse model library and comprehensive downstream analysis services to enhance your understanding of nanoparticle pharmacodynamics. For those interested in an in-depth exploration of pharmacokinetic-pharmacodynamic (PK-PD) relationships and multi-omics analysis in liposomal drug delivery, we possess the necessary expertise to meet your research requirements. Contact us for one-to-one technical support to propel your projects forward and achieve success.

For Research Use Only. Not For Clinical Use