Lipid-Based Drug Delivery Systems in Rheumatoid Arthritis Treatment
Background Creative Biolabs' Solutions Workflow Why Choose Us Published Data FAQs Related Services Resources
Creative Biolabs is your best partner for overcoming challenges with current rheumatoid arthritis (RA) treatments, such as off-target effects, poor drug bioavailability, and high toxicity. Our lipid-based drug delivery service is designed to overcome these obstacles and enhance therapeutic outcomes through advanced drug encapsulation and targeted delivery.
Background of Rheumatoid Arthritis Treatment
RA, accompanied by cartilage and bone destruction, has caused a huge disease burden worldwide. Treatment methods based on non-steroidal anti-inflammatory drugs often have limitations, such as poor bioavailability, high clearance rate, and non-specific effects, which may lead to poor therapeutic effects and increased side effects. As a supplier in the biological field with decades of experience, Creative Biolabs' unique lipid-based drug delivery system development platform is undoubtedly the best choice for your research on RA. We can offer you encapsulation services for anti-inflammatory drugs, increase their dissolution and achieve efficient drug delivery. Please believe that we can solve the precise delivery of most lipid-soluble or water-soluble drugs.
Fig. 1 Liposomes as nanocarriers for the delivery of drugs in the treatment of RA.1,3
How Creative Biolabs' Lipid-Based Drug Delivery Systems Can Assist Your Project
Our LipoDrive™ Platform offers a comprehensive solution to enhance the treatment of rheumatoid arthritis. We offer customized liposome design and development to meet the unique needs of each project, thus ensuring the best results.
|
Liposomes
|
What Can We Do?
|
Advantages
|
Inquire
|
|
Drug-loaded liposomes
|
Based on multiple conjugation techniques, we can modify the surface of liposomes with ligands such as antibodies, RGD peptides and dextran to endow them with active targeting capabilities.
|
Our multiple selectable liposome formulations can achieve efficient encapsulation of anti-inflammatory drugs, thereby preventing their premature release.
|
Inquire
|
|
PEGylated liposomes
|
Prolong the drug's half-life and enhance its therapeutic effect on inflammation.
|
Inquire
|
|
Cationic liposomes
|
Effectively encapsulate negatively charged nucleic acids and increase cellular uptake efficiency.
|
Inquire
|
|
pH-responsive liposomes
|
Utilize pH-sensitive polymers/peptides to enable responsive release in low-pH environments.
|
Inquire
|
Workflow for Lipid-Based Drug Delivery Systems Development for RA
Creative Biolabs' workflow is designed to provide a seamless and efficient experience, ensuring the successful development of your liposomal drug delivery system. With our extensive lipid library and a team of experienced technicians, we then guide you through the entire process of developing liposomes from the ground up. Our streamlined workflow ensures that we can deliver high-quality products in as fast as 4 weeks.
Why Choose Us?
Creative Biolabs is a leader in liposome-based drug delivery, with a proven track record of success in developing innovative solutions for various therapeutic areas. Our expertise in lipid chemistry, drug formulation, and targeted delivery, combined with our state-of-the-art facilities, enables us to provide you with high-quality, customized liposomal products and services. We are committed to advancing the field of nanomedicine and providing our clients with the tools they need to succeed.
-
Dedicated Technical Expertise: Enjoy personalized guidance from our experts, ensuring your project needs are precisely met.
-
Extensive Lipid Experience: Benefit from our profound experience in lipid-based drug delivery, driving innovative and effective solutions.
-
Advanced Freeze-Drying: Enhance liposome stability with our sophisticated freeze-drying technology, simplifying transport and storage.
-
Comprehensive Analytical Platform: Access thorough liposome analysis, including particle size, PDI, zeta potential, and more, through our state-of-the-art characterization tools.
-
Custom Lipid Formulations: we tailor lipid compositions to optimize drug loading, stability, and targeting, aligning with your specific requirements.
-
Versatile Research Support: Utilize our diverse animal models and administration routes to robustly validate the efficacy and safety of your liposomal formulations.
Published Data
The article shows that lipid-based drug delivery systems work for RA treatment. The liposomes concentrate in inflamed joints, correlating with swelling and bone remodeling activity. FL-MTX also reduces liver and kidney elimination of MTX compared to free forms. Overall, FL-MTX is a more effective nano-therapeutic formulation than free MTX, potentially lowering treatment frequency and total dose while maintaining efficacy. This data verifies the feasibility of liposome-based therapies for RA, supporting their potential for efficient treatment of the disease. Creative Biolabs leverages these findings and incorporates the latest advancements in liposome technology to provide cutting-edge solutions.
Fig. 2 Influence of methotrexate (MTX) dose and folate targeting in collagen-induced arthritis CIA mice.2,3
FAQs
Do we need to provide the starting materials?
As a supplier specializing in providing advanced lipid drug delivery solutions, we have a rich lipid library and synthesis capabilities. This enables us to start the project quickly without requiring you to provide lipid and regular drugs.
What's the usual drug loading efficiency of your liposomes?
Our liposomes generally achieve a drug loading efficiency of around 10%.
How are your liposomal products delivered?
We usually deliver liposomal products in lyophilized powder form to ensure stability and prevent issues during transport and storage. However, we also offer liquid delivery if needed.
What production scales can you accommodate?
We can handle production from small laboratory batches to large-scale manufacturing. We're equipped to support your project at any stage of development.
What types of drugs can you encapsulate in liposomes?
Our technology can accommodate most water-soluble and lipid-soluble drugs. We'll assess each project and provide feedback. We're dedicated to ensuring successful drug encapsulation for your project.
Creative Biolabs is committed to providing your RA research with innovative liposome-based drug delivery solutions. In addition, based on one-on-one technical support and rich experience in the development of lipid drug delivery systems, we can provide full assistance throughout your project development. Please contact our team immediately to learn how we can accelerate your drug development process and obtain solutions for RA.
Related Services
Resources
References
-
Hosseinikhah, Seyedeh Maryam, et al. "Nanomaterials for the diagnosis and treatment of inflammatory arthritis." International Journal of Molecular Sciences 22.6 (2021): 3092.
-
Guimarães, Diana, et al. "Folate-targeted liposomal formulations improve effects of methotrexate in murine collagen-induced arthritis." Biomedicines 10.2 (2022): 229.
-
Distributed under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not For Clinical Use
