Lipid-Based Drug Delivery Systems in Psoriasis Treatment

Creative Biolabs is your best partner for overcoming challenges with current psoriasis treatments, such as off-target effects, poor drug bioavailability, and high toxicity. Our lipid-based drug delivery service is designed to overcome these obstacles and enhance therapeutic outcomes through advanced drug encapsulation and targeted delivery.

Background of Psoriasis Treatment

Psoriasis is a chronic inflammatory skin disorder affecting 2-5% of the global population. Current treatments often fail to provide a complete cure, with many available options limited by poor drug penetration, significant side effects. Lipid-based drug delivery systems offer a promising solution to these challenges by improving drug penetration, reducing toxicity, and enhancing efficacy.

Treating psoriasis effectively presents several hurdles, and Creative Biolabs' lipid-based drug delivery systems are designed to address these challenges head-on.

• Skin Barrier Limitations: The stratum corneum is the natural barrier of the skin, which makes it difficult for drugs to penetrate. In psoriasis, thickened and hyperkeratotic plaques further hinder this process. By leveraging the interaction between lipid-based drug delivery systems and skin lipids, we can help you enhance the skin penetration of drugs, thereby increasing treatment efficiency.
• Drug Stability: Many anti-psoriatic drugs, especially biomacromolecules like protein, peptide and nucleic acids, are prone to degradation from environmental factors. By encapsulating anti-psoriatic drugs with liposomes, we can ensure the stability of the drugs during storage and application.
• Poor Drug Solubility: Some drugs like tacrolimus have poor water solubility, affecting absorption. Our lipid-based systems enhance solubility, promoting better absorption and bioavailability.
• Drug Distribution and Precision: Conventional methods often result in shallow, non-specific drug distribution. Our functionalized liposome development services can be used for targeted delivery and controlled release to ensure that anti-psoriatic drugs effectively reach the target regions.

Fig. 1 Multiple drug delivery systems enhance the skin penetration and local targeting of anti-psoriasis drugs.¹

How Creative Biolabs' Lipid-Based Drug Delivery Systems Can Assist Your Project

At Creative Biolabs, we leverage our expertise in lipid-based drug delivery systems, including liposomes and LNPs, to enhance the efficacy of anti-psoriatic drugs. Our comprehensive dermatological administration platform, spanning from delivery system development to in vitro and in vivo pharmacological evaluation, allows for in-depth exploration of psoriasis treatment via topical administration. This includes sophisticated systems like temperature-sensitive and targeted drug delivery, which can significantly improve treatment outcomes.

Workflow for Lipid-Based Drug Delivery Systems Development for Psoriasis

Creative Biolabs believes our lipid delivery systems can revolutionize your psoriasis research. You can find ready-to-use products for psoriasis treatment in our "Drug-loaded Liposomes" section. If you need to develop functionalized delivery systems for psoriasis therapy, please contact us immediately.

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