At present, expensive research in novel drug delivery systems is going on to improve the therapeutic efficacy of the existing natural molecules. Extensive research in the field of herbal drug delivery systems as a means of improving the therapeutic indices of drugs is inevitable and thus phyto-phospholipid complexes came into being. With integrated bioactive molecule development and engineering techniques, Creative Biolabs offers a comprehensive set of vesicular system that provides either individual service modules or final customized products for our valued clients. At present, we are capable to supply various services about phyto-phospholipid complexes. We also provide solutions tailored to our customers’ unique specifications.
Natural products have been frequently used as sources of clinical useful pharmaceuticals. Hydrophilic constituents could be complexed with clinically useful nutrients such as phospholipids to convert them into lipid soluble complexes. This kind of complexes can be used to prepare liposome-like vesicles called phyto-phospholipid complexes. In phyto-phospholipid complexes, the complexation of phospholipids and water soluble active plant components involve chemical bond formation and therefore more stable. However in liposomes no chemical bond is formed and phosphatidylcholine molecules simply surround the water-soluble components. The phyto-phospholipid complexes substantially improve the bioavailability of these hydrophilic active components. Phyto-phospholipid Complexes can easily cross the lipid membranes and are reported to increase the bioavailability of poorly lipid soluble plant based drugs by increasing the absorption in gastrointestinal tract.
Fig.1 Structure of phyto-phospholipid complexes.
In general, the phyto-phospholipid complexes are characterized for physical attributes such as shape, size, its distribution, percentage drug capture, entrapped volume, percentage drug release and chemical composition. For Phyto-phospholipid Complex products numerous studies prove they are markedly better absorbed and have substantially greater clinical efficacy. The phyto-phospholipid complexes technology is a breakthrough model for marked enhancement of bioavailability, significantly greater clinical benefit, and assured delivery to the tissues.
Aided by our well-established platforms and experienced scientists, we can provide comprehensive phyto-phospholipid complexes services, varying from lipid-based drug delivery characterization, delivery system construction services to in vitro efficacy validation, in vivo PK/PD validation. A wide spectrum of customized delivery products is available for your choice.
Phyto-phospholipid Complexes are more bioavailable compared with herbal extracts owing to their enhanced capacity to cross the bio-membranes and thus reaching the systemic circulation. Creative Biolabs is one of the well-recognized experts professional in drug delivery. With years of experience, our scientists can offer high-quality phyto-phospholipid complexes related services and commercial products to meet our customers’ demands. If you are interested in our phyto-phospholipid complexes services, please feel free to contact us for more information.
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