Lipid-Based Drug Delivery Systems in Parkinson's Disease Treatment

Parkinson's disease presents a complex challenge in the realm of neurological disorders. As a leader in the field of drug delivery systems, Creative Biolabs is dedicated to advancing lipid-based approaches that can significantly enhance the treatment landscape for this condition, providing researchers with powerful tools to drive their projects forward.

Background of Parkinson's Disease (PD)

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. It is characterized by the degeneration of dopaminergic neurons in the substantia nigra, leading to dopamine deficiency and resulting in motor, cognitive, sensory, and emotional problems such as tremors, bradykinesia, balance impairment, rigidity, depression, hallucinations, and sleep disorders. PD arises from various mechanisms, including α-synuclein aggregation, neuroinflammation, and mitochondrial dysfunction.

Fig. 1 Pathophysiology of PD.¹

Treatment Strategies for PD

Traditional oral administration for PD treatment faces challenges such as first-pass effects and the barrier of the blood-brain barrier (BBB), which limits the therapeutic efficacy of drugs for PD. The commonly used treatment strategies for PD include:

• Pharmacotherapy: Dopamine replacement is the gold-standard treatment for PD. However, since dopamine cannot cross the BBB directly, levodopa, dopamine receptor agonists (e.g., pramipexole, ropinirole), and MAO-B inhibitors are commonly used in clinical. Yet, long-term use of these drugs is associated with significant side effects and drug resistance.
• Lipid-based Drug Delivery Systems: These systems facilitate drug crossing of the BBB and enhance brain drug concentration through multiple mechanisms, including receptor-mediated transport, endocytosis, carrier-mediated endocytosis, cell-mediated endocytosis, adsorptive-mediated endocytosis, and paracellular diffusion of hydrophilic substances.
• Surface Modification: Surface modification of lipid-based drug delivery systems with ligands such as transferrin, lactoferrin, glucose, glutathione, and angiopep-2 enables the systems to bind to receptors on the BBB, achieving brain-targeted drug delivery.

Creative Biolabs utilizes nano-sized lipid-based drug delivery systems to enable drugs such as dopamine to cross the BBB and be internalized into the brain, thereby prolonging its half-life and achieving efficient PD treatment.

How Creative Biolabs' Lipid-Based Drug Delivery Systems Can Assist Your Project

Creative Biolab offer versatile solutions to enhance PD research. Our systems are designed to improve the effectiveness of PD treatments by ensuring that drugs reach their intended targets in the brain.

• Diverse Administration Routes: We offer non-invasive administration platforms such as transdermal and intranasal drug delivery, which can bypass the barrier effect of the BBB and achieve drug delivery to the brain.
• Gene Therapy: Creative Biolabs' lipid-based drug delivery systems can deliver genes to increase dopamine production or protect neurons.
• Diagnostics and Imaging: Our lipid-based delivery systems have potential applications in PD diagnostics and imaging, enabling more accurate detection and monitoring of the disease. By incorporating diagnostic agents or imaging probes into the lipid formulations, researchers can gain insights into disease progression and treatment response.
• Versatile Lipid-Based Drug Delivery Systems: We have a wide range of well-developed platforms for lipid-based drug delivery systems, including liposome, LNP, nanoemulsion, niosomes, self-emulsifying drug delivery system (SEEDS), solid lipid nanoparticles, etc.

Workflow for Lipid-Based Drug Delivery Systems Development for PD

Creative Biolabs' functionalized delivery system development platform and gene therapy platform can help PD researchers overcome bottlenecks. If you are working on a PD-related research project and want to explore the potential of lipid-based drug delivery systems, we encourage you to contact us. Our dedicated team is ready to collaborate with you and provide tailored solutions to meet your research objectives.

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