At Creative Biolabs, we have engineered a solution to these challenges through an integrated, modular approach. We empower researchers by providing a seamless, one-stop service that covers the entire targeted drug delivery process, from initial concept to preclinical validation.
Get Your Free Consultation Now!Targeted drug delivery is a sophisticated strategy to improve the therapeutic index of drugs by increasing their concentration at a specific site. This is crucial for overcoming biological barriers like cell membranes and the blood-brain barrier.
Successful targeted delivery research requires meticulous planning to overcome persistent biological and technical hurdles. Our expertise is focused on providing solutions to these critical considerations.
The body has evolved multiple defense mechanisms to prevent foreign substances from reaching specific sites. Our solutions navigate barriers including enzymatic degradation, RES clearance, and the blood-brain barrier (BBB).
Delicate therapeutic molecules are highly susceptible to degradation. Our module delivery systems act as protective "nano-shields," safeguarding the payload until it reaches its intended destination.
A key challenge is ensuring high specificity for a disease site while preventing non-specific uptake. Our precision targeting modules minimize off-target effects and maximize therapeutic potential.
A successful targeted delivery system relies on the synergy of two primary components: a Module Delivery System and a Targeting Module.
This is the vehicle that carries and protects the therapeutic payload. Each system is chosen for its unique properties to meet the unique needs of your cargo.
The gold standard for nucleic acid delivery, renowned for their stability and efficiency.
Non-replicative protein structures that mimic viruses, offering efficient delivery.
Polymeric nanoparticles, Nanoemulsions, etc.
This component directs the delivery system to its destination. It can be a molecule that binds to a specific receptor or biomarker on the target cell surface.
Single-stranded nucleic acids that bind to specific molecular targets.
Short chains of amino acids that can be engineered for receptor-mediated targeting.
Highly specific targeting molecules that bind to cellular antigens.
Key components for engineering next-generation delivery systems with built-in targeting capabilities.
Smart materials designed to release their payload in response to specific stimuli (e.g., pH, temperature, enzyme activity) at the target site.
Choosing Creative Biolabs means gaining a trusted partner with the tools and expertise to bring your research to life.
One-stop service from synthesis to validation
Scientists with decades of experience
Diverse range of delivery systems
Rigorous quality control standards
Streamlined workflow to accelerate research milestones
Successful targeted delivery research requires a strategic and collaborative approach. We partner with you to navigate each critical step.
We work with you to clearly define the therapeutic goal, including the specific disease, target cell/tissue, and the therapeutic payload (e.g., siRNA for gene knockdown). This foundational step is crucial for all subsequent design decisions.
Based on your payload and target, our experts will help you select the most suitable modular delivery system, considering factors like encapsulation efficiency, biocompatibility, and stability.
We then identify and synthesize a highly specific targeting module that can effectively guide the delivery system to your chosen target, whether it's a specific cell surface protein or a disease-specific marker.
This is the critical step where the Modular Delivery System is covalently or non-covalently linked to the Targeting Module. Our advanced bioconjugation services utilize state-of-the-art chemical methodologies to ensure a stable, efficient, and reproducible bond.
Once a prototype is developed, we perform rigorous characterization and analytical studies to optimize its physical properties (e.g., size, charge) and ensure its stability.
The final step involves validating the system's performance. We provide comprehensive services to prove targeting specificity, biodistribution, and therapeutic effect in preclinical models.
The strategic application of our one-stop service spans a wide range of therapeutic areas, enabling researchers to achieve their goals with unprecedented precision.
Ideal for delivering genetic material directly to target cells for gene editing or silencing applications.
Customized LNP formulations for mRNA and other nucleic acid-based vaccines.
Precise delivery of chemotherapeutics or immuno-oncology agents to tumor cells.
Conjugated with contrast agents for high-resolution, targeted imaging of specific tissues.
In addition to our custom services, we also offer a variety of high-quality, ready-to-use products designed to accelerate your research. These products are developed and validated to the same rigorous standards as our custom services, providing a reliable and efficient solution for your targeted delivery projects.
Don't let lengthy preparation steps slow down your groundbreaking research. Creative Biolabs offers a comprehensive portfolio of pre-validated, ready-to-use kits designed to streamline your targeted drug delivery projects.
The timeline varies depending on the complexity of the project. Our integrated platform, however, is designed to reduce overall timelines by streamlining the entire workflow and eliminating logistical delays.
We are experts in delivering a vast array of payloads, including small molecules, nucleic acids (mRNA, siRNA, DNA), proteins, peptides, and other bioactive molecules.
Yes. We specialize in the custom synthesis of both module delivery systems and targeting modules to meet your unique research specifications.
Characterization confirms the physical and chemical properties of your product, like size and purity. Validation proves its functional performance in biological systems, such as its targeting specificity.
We adhere to stringent quality control standards throughout the entire process, utilizing cutting-edge analytical techniques to ensure all products and services are consistent and reliable.
Customer Review
Creatibe Biolabs' custom LNP was the only solution that successfully delivered our CRISPR-Cas9 payload across the blood-brain barrier with high efficiency and low toxicity.”
Dr. Evelyn Reed
Postdoctoral Researcher, Leading University
Our siRNA candidate was failing due to off-target toxicity, but Creatibe Biolabs' team rapidly redesigned our LNP using their modular platform, rescuing our preclinical program.”
Ben Carter
Project Manager
Achieving cytosolic delivery of our protein degrader with Creatibe Biolabs' exosome platform was the key to unlocking our candidate's full therapeutic potential.”
Dr. Kenji Tanaka
Principal Scientist, Large Pharma Corp
Our oncology drug's efficacy was limited by poor tumor accumulation. Creatibe Biolabs' peptide-conjugated liposomes provided the precise targeting we needed, dramatically increasing the drug's therapeutic index.”
Dr. Clara Schmidt
Senior Scientist, Oncology Innovations Inc.
We required a delivery system that would only release its payload in the tumor's acidic microenvironment. Creatibe Biolabs' pH-responsive liposomes performed flawlessly, minimizing systemic exposure.”
David Chen
Formulation Scientist
Outstanding expertise in antibody engineering.The team's attention to detail and innovative approaches have sianificantly accelerated our development timeline.
Sarah L.
Senior Research Scientist
