Multidrug resistance-associated protein 1 (MRP1), a 190 kDa protein encoded by the ABCC1 gene, plays an important role in drug and xenobiotic disposition in normal cells and helps protect certain tissues from cytotoxic insults. Nowadays, Creative Biolabs offers comprehensive ABCC1 analysis services for your research needs. Our extensive service experience accumulated over the past years can help you get satisfactory analysis results.
Scientific Validity
Being an ABC transporter, ABCC1 is widely present in various tissues and organs of the human body, and mutations in this gene may cause many disorders or increase their severity. As shown in Fig.1, ABCC1 consists of three membrane-spanning domains (MSD 0-2) and two nucleotide-binding domains (NBD 1-2). Each of the MSD contains several transmembrane segments that transport intracellular materials, while those two NBDs serve as ATP-binding cassettes for the binding and hydrolysis of ATP to power MRP1-mediated transmembrane transport.
Fig.1 Structure of ABCC1.Distributed under CC BY-SA 3.0, from Wiki,
without modification.
ABCC1: mediates drug resistance in tumor cells
Various studies have confirmed that ABCC1 can recognize and expel many hydrophobic and hydrophilic antineoplastic agents, which lead to a weaker drug accumulation and drug resistance of tumor cells. Further studies found that ABCC1 had different resistance to different anticancer drugs. More importantly, the abundant presence of glutathione in cells significantly broadens the range of drugs transported by ABCC1.
Clinical trials have also shown that ABCC1 is involved in the drug resistance process observed in solid tumors such as non-small cell lung cancer, prostate cancer, and some types of breast cancer. Collectively, there is a strong correlation between the expression level of ABCC1 and the therapeutic effect of anticancer drugs.
Services at Creative Biolabs
At present, Creative Biolabs provides full-range analysis services for ABCC1 analysis. In addition, we also offer sophisticated in vitro and in vivo assays tailored to the ABCC1. At Creative Biolabs, high-quality ABCC1-targeting analysis services include but not limited to the following:
- MRP1 level test (ELISA, LFA, CLIA, LEIA, etc.)
- Western blot assay
- MRP1 protein sequencing
- ABCC1 gene test (DNA sequencing, ISH, etc.)
With considerable professional laboratory experts and sophisticated analysis platforms, we are sure to provide you with satisfactory service to solve your various research needs. Creative Biolabs is your best partner for academic research and product development. Since ABCC1 plays a crucial role in the transport of numerous biomolecules, Creative Biolabs also provides tailored services concentrating on its relationship with tumor cell resistance to newly developed drugs.
If there is anything unclear about our ABCC1 analysis services, please do not hesitate to contact us for more details.
For Research Use Only.
