BAZ2A is widely used as a biomarker supporting academic research of prostate cancer diagnosis. As one of the bases for predicting postoperative recurrence time, the BAZ2A protein expression level is also used in the study of chromatin remodeling, regulatory transcription, and DNA-dependent signaling pathways. Here, Creative Biolabs provides a full range of BAZ2A analysis services to support your research needs.
BAZ2A in Cancers
- Prostate Cancer
Studies have shown that high and low expression of BAZ2A can be considered as subtypes of two prostate tumors. Hypermethylation in tumors with high BAZ2A levels was strongly enriched in multi-combination regions compared to normal prostate tissue. Thus, elevated BAZ2A levels are associated with extensive epigenetic remodeling, including functional regions such as promoter and enhancer regions, and multi-combination domains.
BAZ2A related DNA methylation changes involved many genes and pathways known to be associated with prostate cancer, including hypermethylation of prostate cancer-related gene promoters and known inhibition of androgen receptor expression. In prostate tumor cells, 352 genes were suppressed after BAZ2A knockout. And BAZ2A is highly expressed in metastatic prostate cancer.
Fig.1 Binding conformation of acetylpyrrole within the BAZ2A bromodomain.1
- Other Cancers
Distributed under CC BY-SA 3.0, from Wiki,
without modification. Liver Cancer
The high expression of BAZ2A in liver cancer cells has certain influence on the migration and invasion ability of liver cancer cells. The migration and invasion ability of liver cancer cells can be reduced by inhibiting the expression of BAZ2A, to achieve the effect of tumor inhibition.
Distributed under public domain, from Wiki,
without modification. Hepatocellular Carcinoma
In the progression of hepatocellular carcinoma (HCC), BAZ2A gene is up-regulated in HCC tissues, promoting the proliferation, colony formation, migration and EMT of HCC cells.
Distributed under CC BY-SA 4.0, from Wiki,
without modification. Pancreatic Cancer
The abnormal expression of BAZ2A in pancreatic cancer can be used as one of the candidate diagnostic markers.
Services Provided by Creative Biolabs
Future research directions are mainly related to how BAZ2A affects cancer progression, and at which point it exerts its carcinogenic effect. Our services can be customized to suit the specific needs of our clients, popular analysis services targeting BAZ2A include but are not limited to the following:
| Cat | Service |
|---|---|
| BAS108-1 | BAZ2A Antibody Development |
| BAS108-2 | BAZ2A Protein Expression |
| BAS108-3 | BAZ2A Complexes Protein Expression |
| BAS108-4 | BAZ2A Sequence Assay |
| BAS108-5 | BAZ2A-KO Cell Line Construction |
| BAS108-6 | BAZ2A Inhibitor Screening Assay |
| BAS108-7 | BAZ2A Immunohistochemical Analysis |
| BAS108-8 | BAZ2A Immunofluorescence Analysis |
| BAS108-9 | BAZ2A Mass Spectrometry Analysis |
| BAS108-10 | BAZ2A Methylation Assay |
| BAS108-11 | BAZ2A Cell Proliferation Assay |
| BAS108-12 | BAZ2A Cell Apoptosis Assay |
Creative Biolabs is committed to providing the highest quality of custom services and products at the most reasonable prices. Please feel free to contact us for more information.
Reference
- Dalle Vedove, Andrea, et al. "Identification of a BAZ2A-bromodomain hit compound by fragment growing." ACS Medicinal Chemistry Letters 13.9 (2022): 1434-1443. Distributed under CC BY-SA 4.0, without modification.
For Research Use Only.
