ADH5 Analysis

Creative Biolabs focuses on biomarker analysis at the genetic and protein level. We now provide customized alcohol dehydrogenase 5 (ADH5) analysis services for worldwide clients.

Introduction

ADH5 is a 374-amino acid cytoplasmic protein that belongs to the class III subfamily of alcohol dehydrogenases. Expressed ubiquitously, ADH5 uses iron as a cofactor to catalytically oxidize both long-chain primary alcohols and S-hydroxymethyl-glutathione. ADH5 exists as a homodimer and, via its ability to oxidize S-hydroxymethyl-glutathione and, thus, eliminate formaldehyde, functions as an important component of cellular metabolism. Genetic variations in the gene encoding ADH5 may affect drug and alcohol dependence in humans. Two ADH5 polymorphisms are known: ADH5 Val309Ile and ADH5 Asp353Glu.

ADH5 Analysis

Diagnostic Power

In mammals, dysregulation of ADH5 contributes to the pathogenesis of a diverse array of chronic diseases such as fatty liver disease, cardiovascular diseases, and aging. Cellular and animal studies demonstrate that the simultaneous loss of ALDH2 and ADH5 activities leads to an increase in cellular formaldehyde sensitivity and multisystem abnormalities including hematopoietic failure.

We Have Your Biomarker Assay Needs Covered

Human ADH5 shares 90.2% and 92% amino acid (aa) sequence identity with mouse and rat ADH5, respectively. Creative Biolabs has developed high-quality anti-ADH5 monoclonal antibodies suitable for the detection of the ADH5 protein. ADH5 matched antibody pairs are also available for customized immunoassay analysis.

Creative Biolabs also offers a broad spectrum of services including genotyping, SNP, and mutation analysis in genes, as well as a complete analysis of respective target genes or re-sequencing of individual areas of defined genes. Besides, our service portfolio includes comprehensive expression analysis of specific biomarkers.

Introduction

Diagnostic Power

We Have Your Biomarker Assay Needs Covered

Our Service Include but are not limited to: