ABCG5 Analysis - Creative Biolabs

ATP binding cassette subfamily G member 5 (ABCG5) is a key suspect in regulating cholesterol homeostasis in atherosclerotic CVD. Nowadays, Creative Biolabs provides a variety of customized ABCG5 analysis services to support your research.

Scientific Validity

ABCG5 is a transport protein that functions as a half-transporter to limit intestinal absorption and promote the biliary excretion of sterols. ABCG5 and ABCG8 genes encode for two proteins sterolin-1 and -2, respectively. Mutations in either genes result in a lipid disorder, sitosterolemia.

Sitosterolemia is a rare inherited disorder characterized by increased levels of plasma plant sterols (PS) such as stigmasterol, campesterol, and sitosterol. A high level of plasma PS would lead to premature CVD, accelerated atherosclerosis, and sudden cardiac death at an early age. Hence, the identification and analysis of the ABCG5 or ABCG8 gene can be an effective tool for the diagnosis of related diseases such as sitosterolemia.

Fig.1 ABCG5/G8. (Zhang, et al., 2021) Fig.1 Structure of ABCG5/G8.¹

ABCG5 and Gallstones

Certain variations in the ABCG5 gene can increase the prevalence of gallstones in humans. In detail, the bile ducts carry bile produced in the liver to the gallbladder, where it is stored, and then to the small intestine. Recent studies have shown that variations in the ABCG5 gene may lead to the production of a sterol transporter protein that pumps more cholesterol into the bile than usual. This causes cholesterol in the bile ducts and gallbladder to exceed the amount of bile fluid that can be dissolved, leading to the formation of gallstones.

Services at Creative Biolabs

As ABCG5 is of vital importance for the metabolism of sterols, Creative Biolabs provides comprehensive services for ABCG5 identification and quantification. Our popular services targeting ABCG5 include but not limited to the following:

Fig.2 ABCG5 analysis. (Creative Biolabs Original)

Creative Biolabs is a specialized customized service provider in the biological industry. With our advanced technology platform and professional R & D team, we can provide a variety of complex analysis services. There is no doubt that Creative Biolabs will be your most reliable partner for scientific research and drug development.