Recombinant Human CCL2 Protein, Glycoengineered Mannose-5 Pichia pastoris (CAT#: GLJF-0722-JF251)

Product Overview	Recombinant Human CCL2 protein (NP_002973.1) is produced in Glycoengineered Mannose-5 Pichia pastoris. This expression system is used for the production of glycoproteins and antibodies with a mannose-5 structure at N-linked sites.
Source	Glycoengineered Mannose-5 Pichia pastoris
Species	Human
Tag	His-tag, FC-tag
Purity	>90%, determined by SDS-PAGE.
Endotoxin Level	Regular batch
Conjugation	None

Target	CCL2
Full Name	C-C motif chemokine 2
Gene ID	6347
Uniprot ID	P13500
Accession Number	NP_002973.1
Background	This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
Alternate Names	Chemokine (C-C Motif) Ligand 2; Monocyte Chemotactic And Activating Factor 2; Monocyte Chemotactic Protein 1; Monocyte Secretory Protein JE; Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je); Monocyte Chemoattractant Protein-1; Monocyte Chemoattractant Protein 1; Small-Inducible Cytokine A2; SCYA2; MCP-1; HC11; MCAF; MCP1; Small Inducible Cytokine Subfamily A (Cys-Cys), Member; Small Inducible Cytokine Subfamily A (Cys-Cys); Homologous To Mouse Sig-Je; Member 2; HSMCR30; GDCF-2; SMC-CF