The Significance of Compound Analysis Based on Nutrition and Metabolism Research
With the rapid development of the life sciences and healthcare industry, nutrition and metabolism research has become the core driving force for analyzing disease mechanisms, optimizing dietary intervention strategies, and developing personalized medical solutions. The dynamic changes in metabolites serve as the "molecular mirror" of the body's physiological state and pathological processes, and accurate and efficient quantitative analysis of compounds is a key tool for decoding complex metabolic networks. Creative Biolabs has built an advanced Compounds Quantitative Profiling Platform, and we are committed to providing global scientific research institutions with one-stop nutrition and metabolism research-oriented compound analysis solutions, covering the full-dimensional needs from basic target detection to multi-omics integrated research, helping clients seize the initiative in the field of metabolic research.
Core Technology Advantages: Multi-dimensional Analysis Platform Creates Data Gold Standard
We have built a three-in-one technology ecosystem of "chromatography-mass spectrometry-data science" to fully meet the detection needs of different metabolites:
Ultra-high performance liquid chromatography (UHPLC)
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For polar metabolites (such as organic acids, neurotransmitters) and fat-soluble molecules (such as carotenoids, arachidonic acid metabolites), we optimize hydrophilic interaction chromatography (HILIC) and reversed-phase chromatography methods, respectively, to achieve efficient separation of target substances in complex matrices.
High-sensitivity mass spectrometry platform
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Triple quadrupole mass spectrometry (QQQ-MS): Suitable for targeted quantitative analysis (such as bile acid), with a detection limit as low as 0.1 nM and a precision (CV) of <5%.
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High-resolution mass spectrometry (HRMS): Supports non-targeted metabolic profile analysis, combined with an AI-driven compound database (containing 20,000+ metabolites) to achieve rapid identification of unknown substances.
Automated pretreatment system
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Integrate solid phase extraction (SPE), derivatization, and online enrichment technology to overcome the matrix interference problem of trace substances (such as biogenic amines) detection.
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Interdisciplinary data integration capabilities
To break through the limitations of single metabolite detection, we provide:
Multi-omics association analysis
Integrate intestinal microbiome sequencing, transcriptome, and proteome data to build a "microbiome-host-metabolite" interaction network.
Dynamic modeling of metabolic pathways
Based on the KEGG databases, visualize the biological significance of the target in energy metabolism, inflammation regulation, or oxidative stress pathways.
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Full process standardization and traceability
From sample pretreatment to data delivery, we have established a strict full-process standardization system to ensure the reliability and traceability of data.
Core Service Scope: Focus on Key Targets in Metabolic Research
Our portfolio of targeted quantitative analysis services covers a broad spectrum of critical compounds in nutrition and metabolism, each offering unique insights:
Organic Acid Quantitative Analysis Service
This service provides a comprehensive profile of organic acids, which are key intermediates in central metabolic pathways (e.g., glycolysis, fatty acid oxidation). Their levels can indicate nutrient deficiencies, mitochondrial dysfunction, and imbalances in gut microbiome activity, offering a window into overall metabolic health.
Bile Acid Quantitative Analysis Service
Bile acids are crucial for lipid digestion and absorption, but they also act as signaling molecules regulating glucose, lipid, and energy metabolism. Our analysis helps elucidate their roles in liver diseases, gut microbiota interactions, and metabolic syndromes.
Arachidonic Acid Quantitative Analysis Service
Arachidonic acid and its metabolites (eicosanoids like prostaglandins, leukotrienes) are potent lipid mediators involved in inflammation, immune responses, and cardiovascular function. This service offers precise quantification to understand their contribution to pathological and physiological processes.
Carotenoid Quantitative Analysis Service
Carotenoids are a diverse group of plant pigments with significant antioxidant properties, essential for vision, immune function, and cellular protection. Quantifying these compounds provides insights into dietary intake, antioxidant status, and their potential role in disease prevention.
Catechin Quantitative Analysis Service
Catechins are a class of flavonoids found abundantly in tea and fruits, renowned for their potent antioxidant and anti-inflammatory activities. Our analysis helps assess their bioavailability, metabolism, and impact on human health, particularly in cardiovascular and metabolic health.
Anthocyanin Quantitative Analysis Service
Anthocyanins are vibrant pigments responsible for the red, purple, and blue colors in fruits and vegetables. They possess strong antioxidant and anti-inflammatory properties. This service quantifies these bioactive compounds to understand their health-promoting effects.
Biogenic Amine Quantitative Analysis Service
Biogenic amines are nitrogenous compounds formed through decarboxylation of amino acids, playing roles as neurotransmitters, hormones, and modulators of various physiological processes. Their analysis can shed light on gut health, neurological function, and food safety.
Alkaloid Quantitative Analysis Service
Alkaloids are a diverse group of naturally occurring chemical compounds, often found in plants, with significant pharmacological activities. Our service quantifies these compounds to explore their potential therapeutic applications or assess their presence in food and botanical supplements.
Flavonoid Quantitative Analysis Service
Flavonoids represent a vast class of plant secondary metabolites widely distributed in fruits, vegetables, and beverages. They are recognized for their antioxidant and cardioprotective effects. This analysis provides a comprehensive profile of various flavonoid subclasses.
Neurotransmitter Quantitative Analysis Service
Neurochemicals known as neurotransmitters serve as vital signaling molecules that facilitate communication between neurons within neural networks. Quantifying their levels provides critical data for research into neurological disorders.
Trimethylamine N-oxide (TMAO) Quantitative Analysis Service
TMAO is a gut microbiota-dependent metabolite that has gained significant attention for its association with cardiovascular disease risk. Our service provides precise quantification of TMAO, enabling researchers to investigate its role in cardiometabolic health and dietary interventions.
Service Process: Efficient Response, Worry-free Throughout the Process
Demand communication
Professional technical team responds within 24 hours, provides free solution consultation, and supports customized testing packages.
Sample submission
Provide standardized sampling and pretreatment guidelines.
Laboratory analysis
Our expert team performs the quantitative analysis for samples.
Data processing and reporting
Deliver comprehensive project reports and result analysis.
Post-analysis support
Provide follow-up consultations to discuss the results, assist with data interpretation.
Why Partner with Us?
Choosing the right analytical partner is important for the success of your research. We stand apart through:
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Precision and accuracy: Our unwavering commitment to delivering highly accurate and reproducible quantitative data.
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Scientific acumen: A team of dedicated experts who understand the nuances of nutrition and metabolism.
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Customization: Flexible service offerings tailored to your unique research requirements.
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Various technologies: Access to the latest and most robust analysis platforms.
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Comprehensive assistance: From initial consultation to analysis interpretation, we are your dedicated scientific partner.
Unlock the full potential of your nutrition and metabolism research with Creative Biolabs' advanced compound analysis services. We invite you to connect with our team to discuss your specific project needs, explore our capabilities, and receive a customized quotation. Let us be your trusted partner in the complex world of metabolic science. Please contact us to obtain more information about our services and to request a personalized price inquiry.
FAQs
Q1: How can your compound analysis services specifically help my research?
A1: Our services help by providing precise quantitative data on key metabolites relevant to your specific research area. For example, in diabetes research, we can analyze organic acids and bile acids to understand metabolic dysregulation. For gut health, we can assess biogenic amines and TMAO, which are influenced by microbial activity. We tailor our analysis to your research question, helping you identify biomarkers, understand disease mechanisms, or evaluate intervention efficacy.
Q2: You mention a "three-in-one technology ecosystem." Can you elaborate on how chromatography, mass spectrometry, and data science synergize in your platform?
A2: Chromatography (like UHPLC) first separates the complex mixture of compounds in a sample. MS (like QQQ-MS) then detects and quantifies these separated compounds according to their mass-to-charge ratio, providing high sensitivity and specificity. Finally, data science, including our AI-driven compound database, processes this vast amount of data, identifies known and potentially unknown compounds, performs statistical analysis, and helps in pathway mapping and biological interpretation. This synergy ensures comprehensive and accurate metabolic profiling.
Q3: How does your automated pretreatment system specifically overcome matrix interference for trace substances like biogenic amines?
A3: Our automated pretreatment system integrates techniques like SPE and derivatization. SPE selectively isolates biogenic amines from complex sample matrices (like plasma or food extracts), removing interfering substances. Derivatization can enhance their chromatographic properties and ionization efficiency for mass spectrometry, improving sensitivity and detectability, especially when they are present at trace levels. Automation ensures consistency and minimizes sample handling variability.
Customer Review
Exceptional Turnaround Time
"We were particularly impressed by the exceptional turnaround time for our neurotransmitter quantitative analysis. Despite the complexity of the samples and the volume requested, your team delivered the comprehensive report well within the agreed-upon timeframe, significantly accelerating our research timeline without compromising data quality." - Dr. A. Sm***h
Tailored Analysis Approaches
"We appreciated the tailored analysis approaches for our specific flavonoid compounds. Your team demonstrated remarkable flexibility and expertise in developing a customized method that precisely met the unique challenges of our complex sample matrix, ensuring accurate and reliable results." - Prof. B. Jo***s
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