Service at Creative Biolabs: Precision in Glycoscience

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Custom Synthesis Services

At Creative Biolabs, we specialize in tailoring glycan-related molecules to accelerate your discovery and development goals. Whether you are engineering biotherapeutics or designing tools for glycomics research, our custom synthesis services provide unparalleled control over structure, functionality, and site specificity. From monosaccharides to complex glycoproteins, we offer modular, scalable synthesis platforms:

Custom Glycan Synthesis Services

Generate defined oligosaccharide structures—including N-glycans, O-glycans, and rare monosaccharides—with precise linkages and stereochemistry. Options include total chemical synthesis, chemoenzymatic assembly, and automated glycan generation.

Custom Glycopeptide Synthesis Services

We produce structurally homogeneous glycopeptides with defined glycosylation patterns using solid-phase peptide synthesis (SPPS) and site-directed glycan conjugation. This service supports epitope mapping, glycan-array development, and vaccine design.

Custom Glycoprotein Synthesis Services

Our glycoprotein platform integrates recombinant expression with in vitro glycoengineering, enabling site-specific glycoform customization. Ideal for preclinical screening, therapeutic optimization, or biomarker validation.

Oligosaccharide Library Development Service

Build comprehensive glycan libraries for high-throughput screening, binding assays, or structure-activity studies. Libraries are customizable in terms of sugar type, length, branching, and functional groups.

Therapeutic Glycoprotein Development Services

As glycosylation plays a pivotal role in modulating therapeutic protein stability, activity, and immunogenicity, the development of glycoprotein-based biologics demands both precision and flexibility. At Creative Biolabs, we specialize in tailored glycoengineering strategies for therapeutic proteins, integrating advanced expression platforms with state-of-the-art glycan analysis. Whether you are optimizing Fc glycosylation for enhanced ADCC or developing glycoform-specific variants for improved PK profiles, our customizable solutions support every stage of therapeutic glycoprotein development—from host cell line engineering to analytical validation. Learn how our comprehensive platform enables the design, production, and characterization of glycoproteins with defined glycosylation profiles.

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Glycoprotein Analysis Services

Accurate and scalable glycoprotein analysis is therefore indispensable for biopharmaceutical development, disease biomarker discovery, and functional proteomics. At Creative Biolabs, we offer a comprehensive glycoprotein analysis platform that integrates leading-edge detection, quantification, structural elucidation, and sample-specific glycoprofiling technologies to meet diverse research and development goals.

Glycoprotein Detection

The initial step in any glycosylation-focused study is to determine the presence and abundance of glycoproteins. Our glycoprotein detection services utilize state-of-the-art methods including lectin-based assays, fluorescence imaging, and antibody-overlay strategies to sensitively capture glycoproteins in various biological matrices.

In-Depth Structural Analysis of Glycoproteins

Glycosylation site occupancy and glycan heterogeneity are crucial parameters in functional studies and therapeutic development. Our glycoprotein structure analysis services combine bottom-up glycoproteomics with top-down MS profiling to provide:

Site-specific N- and O-glycosylation mapping
Intact glycopeptide characterization
Branching pattern and linkage determination

High-Throughput Glycoprofiling

We support scalable glycan profiling for hundreds of samples daily using robotic sample preparation and sensitive detection platforms. Our high-throughput glycan screening service enables:

Fluorescently labeled glycan detection
Capillary electrophoresis or UHPLC-FLD quantification
Profiling of N- and O-glycans at the site-specific level

Specialized Services for Complex Samples

Glycosylation is highly context-dependent. We offer tailored profiling services for various sample types:

Viral Glycoprotein Characterization

Glycosylation critically affects antibody effector function, immunogenicity, and serum half-life. Our glycosylation analysis services for virus glycoprotein are optimized for profiling envelope proteins, enabling batch consistency and vaccine candidate evaluation.

Glycoprotein Component-Level Quantification

Quantitative assessment is supported by our glycoprotein quantification service, optimized for high-throughput workflows using advanced HPLC, CE-LIF, and MS-based technologies. For researchers needing glycan composition data, Creative Biolabs also offers:

Carbohydrate Analysis Services

Carbohydrates, including mono-, oligo-, and polysaccharides, play essential roles in biological systems, from structural integrity to cell signaling. At Creative Biolabs, our carbohydrate analysis services offer a complete suite of analytical solutions to decode the complexity of carbohydrate structures, aiding basic research development. To better support diverse research objectives, we provide specialized sub-services tailored to different carbohydrate classes:

Monosaccharides Analysis

Oligosaccharides Analysis

Polysaccharides Analysis

Glycan Modification and Labeling Services

Our services encompass a range of chemical and enzymatic strategies to modify glycan structures, thereby influencing glycoprotein behavior, stability, and interactions. Each of our services is tailored to meet specific research needs, ensuring precise and efficient modification of glycoproteins. Our team of experts employs state-of-the-art techniques to deliver high-quality results that advance your research.

Fluorescence Labeling

We provide fluorescence labeling services that attach fluorescent tags to glycoproteins, facilitating visualization and tracking in various biological assays.

Biotinylation

Our biotinylation service introduces biotin moieties to glycoproteins, enabling strong and specific binding to streptavidin or avidin, which is useful in purification and detection protocols.

PEGylation

Through PEGylation, we conjugate polyethylene glycol chains to glycoproteins, enhancing their solubility, stability, and half-life.

Isotope Labeling

Our isotope labeling service incorporates stable isotopes into glycoproteins, aiding in quantitative proteomics and metabolic studies by allowing precise tracking and analysis.

Sulfate Modification

We offer sulfate modification to introduce sulfate groups into glycan structures, which can modulate biological activity and interactions, especially in cell signaling pathways.

Phosphorylation Modification

Our phosphorylation modification service adds phosphate groups to glycoproteins, impacting their function and recognition in various biological processes.

Acetylation Modification

Through acetylation, we modify glycoproteins to influence their stability and interactions, which can be critical in regulating protein function and localization.

Glycoconjugation

At Creative Biolabs, we offer comprehensive glycoconjugation services to facilitate the study and application of glycoconjugates in various biological contexts. Our expertise encompasses the conjugation of carbohydrates to proteins, peptides, oligonucleotides, and other biomolecules, enabling the exploration of glycan functions and interactions. Our services include:

Fig.1 Various types of glycoconjugates.¹

At Creative Biolabs, we offer comprehensive glycoconjugation services to facilitate the study and application of glycoconjugates in various biological contexts. Our expertise encompasses the conjugation of carbohydrates to proteins, peptides, oligonucleotides, and other biomolecules, enabling the exploration of glycan functions and interactions. Our services include:

Custom conjugation strategies
High-quality reagents and protocols
Analytical support

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Glycoengineering Services

Therapeutic Protein Glycoengineering

We employ advanced platforms—including cell-based genetic and metabolic engineering, chemoenzymatic methods, and cell-free systems—to produce therapeutic proteins with customized glycan patterns. These modifications can improve pharmacokinetics, reduce immunogenicity, and enhance bioactivity.

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Therapeutic Antibody Glycoengineering

Our antibody glycoengineering services focus on modifying Fc glycosylation to optimize effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). By controlling glycan structures, we enhance antibody stability and performance.

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Cell Line Glycoengineering

We offer cell line glycoengineering services to develop production systems capable of generating glycoproteins with desired glycosylation profiles. Our strategies include genetic modifications to host cells, enabling the production of glycoproteins with improved properties.

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Other Service Portfolio

Bioactive Carbohydrates Screening

Our screening services focus on identifying bioactive carbohydrates, particularly those associated with cancer. Utilizing advanced equipment, we aim to discover novel carbohydrate-based pharmaceuticals.

Tumor Glyco-diag

We provide tumor glyco-diagnostic services, leveraging our expertise in tumor-associated glycans to support cancer research and diagnostics. Our services aim to enhance research productivity and streamline processes.

Anti-Glycoprotein Antibody Development

Through our Anti-Gly™ platform, we develop custom anti-glycoprotein antibodies using technologies like phage display, hybridoma and antigen-specific B cells sorting platform. This supports the development of specific antibodies for research purposes.

Glyco-based Vaccine Development

We specialize in developing glycoprotein-based vaccines, employing glycoengineered platforms and chemoenzymatic methods. Our comprehensive services cover vaccine candidate development and characterization.

Glycoproteomics-based Liquid-biopsy LDT Development

Our services include the development of glycoproteomics-based liquid-biopsy laboratory-developed tests (LDTs), focusing on characterizing and quantifying glycoproteins and their glycan structures for various cancer types.

Glycan-related Enzyme Activity Analysis

We offer enzyme activity analysis services to elucidate the roles of glycan-related enzymes in biological processes, aiding in the optimization of saccharification and fermentation processes.

Biomass Components Quantitative Profiling

Our profiling services provide detailed analysis of biomass components, assisting clients in understanding lignocellulose composition and optimizing the use of biomass resources.

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Engage with our team of seasoned experts to explore how our cutting-edge platforms and unwavering 100% commitment to innovation and precision can elevate your projects. Whether you seek customized strategies, technical expertise, or collaborative insights, we're here to design solutions that align seamlessly with your goals. Reach out now for a personalized consultation and competitive quote – let's transform your vision into actionable results, together.

Reference

Wilczak, Magdalena, Magdalena Surman, and Małgorzata Przybyło. "Altered glycosylation in progression and management of bladder cancer." Molecules 28.8 (2023): 3436. Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.3390/molecules28083436