Introduction of Biogenic Amine Quantitative Analysis Service
Biogenic amines (BAs) are vital low-molecular-weight compounds that are crucial for neurological, cardiovascular, and immune functions. Their precise quantification in biofluids serves as a powerful biomarker for disease diagnosis and progression. Furthermore, in food products, their levels are critical indicators of safety and quality, particularly in fermented and aquatic items. Creative Biolabs stands at the forefront of BA quantitative analysis, offering unparalleled expertise, advanced technology, and a steadfast commitment to client success. Our unique advantages stem from decades of specialized experience and continuous innovation in the field. We understand the nuances of diverse sample matrices and the critical need for both sensitivity and specificity in biogenic amine detection.
How to Analyze the BA in the Samples?
Creative Biolabs provides a versatile suite of BA quantitative analysis services tailored to specific research and industry requirements. Our approach to analyzing BAs in samples is comprehensive, integrating advanced methodologies to ensure optimal results. Our analytical process combines sophisticated sample preparation with highly sensitive detection techniques to overcome the inherent challenges of complex biological and food matrices. Our service delivers accurate concentration data, detailed analytical reports, and expert interpretation, enabling robust biomarker validation, enhanced food safety monitoring, and informed decision-making in your research or product development. We help you overcome the complexities of matrix interference and low-concentration detection, ensuring reliable results for even the most challenging samples.
Our expert team collaborates with you to understand your specific project goals, sample types, and analytical needs. We define the scope, select appropriate methodologies, and establish a clear timeline. This ensures the analytical approach is perfectly aligned with your objectives.
This crucial stage involves meticulous handling and processing of your samples. Depending on the matrix complexity and target amines, we employ advanced techniques such as solid-phase extraction (SPE), magnetic solid-phase extraction (MSPE), or molecularly imprinted solid-phase extraction (MISPE) to isolate and enrich BAs, minimizing matrix interference and enhancing detection sensitivity.
Prepared samples undergo rigorous analysis using our state-of-the-art Metabolism Analysis platforms, including highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) systems. We select the most appropriate method according to the target amines and sample characteristics, ensuring optimal separation and precise quantification.
Fig.1 BA analysis content provided by Creative Biolabs.
Raw data is processed using advanced bioinformatics tools. Comprehensive quality control measures, including calibration curves, internal standards, and replicate analyses, are applied to ensure the accuracy, reproducibility, and reliability of all quantitative results.
We generate detailed analytical reports, and our scientists are available to discuss the results and their implications for your project.
At Creative Biolabs, we are dedicated to empowering your scientific discoveries and ensuring product excellence through precise and reliable BA quantification. Our expert team is ready to discuss your specific needs and tailor a solution that drives your project forward. We also provide various quantitative analysis services, including Organic Acid, Arachidonic Acid, Catechin, Alkaloid, Flavonoid, and Neurotransmitter quantitative analysis services. Please contact us to inquire about more details if you would like to obtain analysis services.
Published Data
This research investigates the presence and levels of BAs in various cheese samples. The study aims to characterize the amine profiles across different cheese types and maturation stages, providing insights into food safety and quality aspects. By analyzing the concentrations of individual amines, the authors seek to understand how factors like origin and ripeness influence the biochemical composition of cheese. Specifically, a visual representation, such as a heat map, illustrates the distinct patterns of amine accumulation in the cheese samples. This graphic effectively highlights the differences in both the individual and overall quantities of amines present in fresh versus aged cheeses, as well as between products from farmstead and retail environments. The visual also clearly delineates the relative contribution of each specific amine to the total amine content within the diverse cheese samples examined in this investigation. This allows for a quick grasp of which amines are predominant in certain cheese categories or stages of development.
Fig.2 Results of the heatmap analysis of fresh and mature cheese samples.1
FAQs
Q1: What are the typical turnaround times for your BA analysis service?
A1: Our standard turnaround time typically ranges from 3 to 5 weeks, depending on the complexity of your samples and the scope of the project. We understand the importance of timely results for your research and are always transparent about timelines during the project planning phase. For urgent needs, please discuss your specific requirements with our team.
Q2: What types of samples can Creative Biolabs analyze for BAs?
A2: We have extensive experience analyzing a wide range of biological samples, including plasma, serum, urine, and tissue homogenates. Additionally, our expertise extends to various food matrices such as fish products, cheeses, fermented foods, and beverages. If you have a unique sample type, please reach out for a personalized consultation!
Q3: Can you help with custom BA panels or method development for specific research questions?
A3: Absolutely! We specialize in developing customized analytical solutions. If your project requires the quantification of a specific panel of BAs not covered by our standard offerings, or if you need method development for a novel sample type, our expert scientific team is ready to collaborate with you. We thrive on solving unique analytical challenges.
Customer Review
Critical for Our Food Safety Program
"Creative Biolabs' BA quantitative analysis service has been critical for our seafood quality control. Their ability to accurately detect histamine and other biogenic amines in various fish products, even at trace levels, has allowed us to implement proactive measures, prevent spoilage, and ensure consistent product safety for our consumers. Their team's expertise in handling complex food matrices is truly impressive." - Mr. O. Tay***r
Streamlined Biomarker Validation
"The Creative Biolabs BA quantitative analysis service streamlined our biomarker validation efforts for cardiovascular disease. Their robust reproducibility and high throughput capabilities meant we could process a large cohort of plasma samples efficiently, obtaining reliable data that significantly advanced our clinical study." - Dr. P. And***n
Reference
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Kandasamy, Sujatha, et al. "Quantitative analysis of biogenic amines in different cheese varieties obtained from the Korean domestic and retail markets." Metabolites 11.1 (2021): 31. DOI: 10.3390/metabo11010031. Distributed under an Open Access license CC BY 4.0, without modification.
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