We specialize in the synthesis of historically challenging mannose linkages, including C-glycosides, thio-glycosides, and complex multivalent structures, opening new avenues for drug design.
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Mannosylation is a foundational modification critical to host-pathogen interaction, immune regulation, and cellular signaling. Defined mannose glycans are indispensable tools for studying pathogen recognition (e.g., HIV, SARS-CoV-2 spike protein), developing novel prophylactic vaccines, and probing innate immunity via key pattern recognition receptors. Furthermore, aberrations in mannosylation are increasingly implicated in congenital disorders of glycosylation (CDG), rheumatoid arthritis (autoimmune diseases), and driving cancer metastasis via altered cell-surface presentation. At Creative Biolabs, we eliminate the complexity and inherent variability of isolating and characterizing these vital structures from biological sources. We offer the most comprehensive and high-purity Glycan Libraries available globally, including N-Glycan, O-Glycan, mannose glycan, Lacto Glycan, and Glycosaminoglycan Libraries, delivered via robust chemical synthesis to empower your breakthrough discoveries and ensure regulatory compliance.
The profound biological functions of mannose glycans are dictated by the subtle differences in their linkages (alpha-1,2, alpha-1,3, alpha-1,6) and intricate branching patterns. The precise, non-enzymatic control over this structural complexity is the defining principle of our library.
| Common Mannose Glycan Structures | ||
CAT#: GLJF-1125-HX484
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CAT#: GLJF-1125-HX485
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CAT#: GLJF-1125-HX486
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CAT#: GLJF-1125-HX487
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CAT#: GLJF-1125-HX488
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CAT#: GLJF-1125-HX489
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CAT#: GLJF-1125-HX490
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CAT#: GLJF-1125-HX491
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CAT#: GLJF-1125-HX492
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CAT#: GLJF-1125-HX493
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CAT#: GLJF-1125-HX494
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CAT#: GLJF-1125-HX495
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CAT#: GLJF-1125-HX496
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CAT#: GLJF-1125-HX497
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CAT#: GLJF-1125-HX498
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We provide tailored solutions for every stage of glycomics research and development, from initial, exploratory screening to large-scale development and quality control.
Our product line is designed for researchers requiring structural diversity, guaranteed high purity, and immediate availability of essential mannosylated building blocks.
Table 1 Properties and applications of the mannan glycan library.
| Feature | Description | Application Focus |
|---|---|---|
| High-mannose series | These intermediates are crucial for protein folding, the ER-associated degradation pathway, and serve as targets for HIV-1 neutralizing antibodies. We offer both the reducing and non-reducing forms. | Virology, Quality Control, Cell Biology. |
| Linear & branched structures | Defined single-residue mannosides, Man-alpha-1,2/3/6-Man dimers, and complex oligomannosides up to 15 residues. | Receptor Binding Studies, Lectin Profiling, Microbial Glycobiology. |
| Guaranteed purity | Every compound is rigorously synthesized and provided with comprehensive analytical data. We ensure stringent lot-to-lot consistency via dedicated quality control procedures. | Ensuring reproducible and reliable experimental results. |
If your research demands a unique, non-standard mannose structure or large-scale production, our expert chemists are ready to execute your vision with unparalleled precision.
We specialize in the synthesis of historically challenging mannose linkages, including C-glycosides, thio-glycosides, and complex multivalent structures, opening new avenues for drug design.
Production of modified mannose glycans featuring isotopic labels for advanced NMR structural elucidation, photoaffinity probes for identifying novel binding sites, or specific chemical handles (e.g., N-terminal amino groups, terminal azide/alkyne) for efficient, highly selective click chemistry conjugation to proteins or surfaces.
We master the full spectrum of carbohydrate chemistry, utilizing state-of-the-art automated solid-phase synthesis for rapid library generation alongside high-yield classic solution-phase methods, enabling efficient scale-up from milligrams to multi-kilogram quantities required.
Accelerate your screening process, validate targets, and precisely understand binding specificities rapidly and efficiently with our proprietary glycan array technology. Featuring dozens to hundreds of diverse mannose glycans, the arrays utilize optimized immobilization chemistries to ensure correct glycan presentation.
We offer stable, functionally validated, and ready-to-use conjugates and probes that bypass the need for complex, time-consuming internal labeling and purification steps, saving you valuable time and resources.
Mannose glycans attached via stable, biologically inert linkers to a high-purity biotin tag. These are the gold standard for use in highly sensitive ELISA, Western Blotting, affinity purification columns, and magnetic bead-based cell separation.
Covalently linked conjugates with commonly used, stable fluorophores (e.g., FITC, Cy3) for direct visualization in live-cell imaging, flow cytometry analysis of receptor expression, and high-resolution plate-based binding assays.
Mannose structures covalently linked to immunogenic carrier proteins (e.g., BSA, KLH) via optimized and reproducible linker technologies. These are essential tools for the rapid generation of high-titer anti-glycan antibodies and use as immunogens in conjugate vaccine development.
Ready to accelerate your research into infectious diseases, immunology, drug delivery, and cancer? Stop relying on unreliable biological sources and embrace the precision, scalability, and quality of defined synthetic glycans. Contact Creative Biolabs' sales team or scientific support specialists for personalized pricing, detailed library specifications, and to schedule a consultation on a complex custom synthesis project.