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Mannose Glycan Library Products

Various Mannose Glycan Library

Mannosylation is a foundational modification critical to host-pathogen interaction, immune regulation, and cellular signaling. Defined mannose glycans are indispensable tools for studying pathogen recognition (e.g., HIV, SARS-CoV-2 spike protein), developing novel prophylactic vaccines, and probing innate immunity via key pattern recognition receptors. Furthermore, aberrations in mannosylation are increasingly implicated in congenital disorders of glycosylation (CDG), rheumatoid arthritis (autoimmune diseases), and driving cancer metastasis via altered cell-surface presentation. At Creative Biolabs, we eliminate the complexity and inherent variability of isolating and characterizing these vital structures from biological sources. We offer the most comprehensive and high-purity Glycan Libraries available globally, including N-Glycan, O-Glycan, mannose glycan, Lacto Glycan, and Glycosaminoglycan Libraries, delivered via robust chemical synthesis to empower your breakthrough discoveries and ensure regulatory compliance.

Mannose Glycan Structural Diversity

The profound biological functions of mannose glycans are dictated by the subtle differences in their linkages (alpha-1,2, alpha-1,3, alpha-1,6) and intricate branching patterns. The precise, non-enzymatic control over this structural complexity is the defining principle of our library.

Common Mannose Glycan Structures
CAT#: GLJF-1125-HX484 CAT#: GLJF-1125-HX485 CAT#: GLJF-1125-HX486
CAT#: GLJF-1125-HX487 CAT#: GLJF-1125-HX488 CAT#: GLJF-1125-HX489
CAT#: GLJF-1125-HX490 CAT#: GLJF-1125-HX491 CAT#: GLJF-1125-HX492
CAT#: GLJF-1125-HX493 CAT#: GLJF-1125-HX494 CAT#: GLJF-1125-HX495
CAT#: GLJF-1125-HX496 CAT#: GLJF-1125-HX497 CAT#: GLJF-1125-HX498

Explore Our Comprehensive Mannose Glycan Portfolio

We provide tailored solutions for every stage of glycomics research and development, from initial, exploratory screening to large-scale development and quality control.

  • The Core: Mannose Glycan Libraries & Individual Oligosaccharides

Our product line is designed for researchers requiring structural diversity, guaranteed high purity, and immediate availability of essential mannosylated building blocks.

Table 1 Properties and applications of the mannan glycan library.

Feature Description Application Focus
High-mannose series These intermediates are crucial for protein folding, the ER-associated degradation pathway, and serve as targets for HIV-1 neutralizing antibodies. We offer both the reducing and non-reducing forms. Virology, Quality Control, Cell Biology.
Linear & branched structures Defined single-residue mannosides, Man-alpha-1,2/3/6-Man dimers, and complex oligomannosides up to 15 residues. Receptor Binding Studies, Lectin Profiling, Microbial Glycobiology.
Guaranteed purity Every compound is rigorously synthesized and provided with comprehensive analytical data. We ensure stringent lot-to-lot consistency via dedicated quality control procedures. Ensuring reproducible and reliable experimental results.

If your research demands a unique, non-standard mannose structure or large-scale production, our expert chemists are ready to execute your vision with unparalleled precision.

Novel linkages & architecture

We specialize in the synthesis of historically challenging mannose linkages, including C-glycosides, thio-glycosides, and complex multivalent structures, opening new avenues for drug design.

Unnatural derivatives & functionalization

Production of modified mannose glycans featuring isotopic labels for advanced NMR structural elucidation, photoaffinity probes for identifying novel binding sites, or specific chemical handles (e.g., N-terminal amino groups, terminal azide/alkyne) for efficient, highly selective click chemistry conjugation to proteins or surfaces.

Scalability

We master the full spectrum of carbohydrate chemistry, utilizing state-of-the-art automated solid-phase synthesis for rapid library generation alongside high-yield classic solution-phase methods, enabling efficient scale-up from milligrams to multi-kilogram quantities required.

  • High-Throughput Screening

Accelerate your screening process, validate targets, and precisely understand binding specificities rapidly and efficiently with our proprietary glycan array technology. Featuring dozens to hundreds of diverse mannose glycans, the arrays utilize optimized immobilization chemistries to ensure correct glycan presentation.

  • Mannosylated Glycoconjugates & Probes

We offer stable, functionally validated, and ready-to-use conjugates and probes that bypass the need for complex, time-consuming internal labeling and purification steps, saving you valuable time and resources.

Biotin conjugates

Mannose glycans attached via stable, biologically inert linkers to a high-purity biotin tag. These are the gold standard for use in highly sensitive ELISA, Western Blotting, affinity purification columns, and magnetic bead-based cell separation.

Fluorescent probes

Covalently linked conjugates with commonly used, stable fluorophores (e.g., FITC, Cy3) for direct visualization in live-cell imaging, flow cytometry analysis of receptor expression, and high-resolution plate-based binding assays.

Protein conjugates

Mannose structures covalently linked to immunogenic carrier proteins (e.g., BSA, KLH) via optimized and reproducible linker technologies. These are essential tools for the rapid generation of high-titer anti-glycan antibodies and use as immunogens in conjugate vaccine development.

Take the Next Step: Request Your Quote Today

Ready to accelerate your research into infectious diseases, immunology, drug delivery, and cancer? Stop relying on unreliable biological sources and embrace the precision, scalability, and quality of defined synthetic glycans. Contact Creative Biolabs' sales team or scientific support specialists for personalized pricing, detailed library specifications, and to schedule a consultation on a complex custom synthesis project.

For Research Use Only.

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