PharmaOnco™ CHO-Tg(Human Claudin 18.2) Stable Cell Line, Single Clone

Creative Biolabs offers CHO-Tg(Human Claudin 18.2) stable cell line which the Claudin 18.2 gene stably expressed in CHO cells.

CHO-Tg(Human Claudin 18.2) stable cell line is a cell line derived from Chinese Hamster Ovary (CHO) cells that has been engineered to express the human Claudin 18.2 protein in a stable and consistent manner. Claudin 18.2 is a tight junction protein that plays a key role in the regulation of paracellular permeability in epithelial cells. This cell line can be used in various research applications, such as studying the function of Claudin 18.2 in cell adhesion, barrier formation, and disease pathology. It can also be used in drug screening studies to evaluate the effects of potential therapeutics on Claudin 18.2 function.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

Claudin 18.2

Human

CHO

The Claudin 18.2 gene (CLDN18.2) encodes a protein that is a member of the claudin family of tight junction proteins. Tight junctions are specialized structures that regulate the passage of ions and small molecules between cells, controlling the paracellular transport of substances across epithelial and endothelial cell layers. Claudin 18.2 is specifically expressed in the stomach and has been identified as a potential therapeutic target for gastric cancer. It is highly expressed in various types of gastric cancer cells and plays a critical role in the progression and invasion of the disease.

1 x 10e6 cells/vial, Frozen

Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.

Identity testing is required for newly established cell lines. Isoenzyme analysis is used to confirm the identity of the species of a cell line. Alternative methods for identity testing include DNA fingerprinting, STR analysis and karyology.

A broad range of viruses is susceptible to affecting human cell lines. We can provide in vivo/vitro virus safety assays by utilizing various animal systems. These viruses include: adventitious viruses, bovine viruses, human and simian viruses, porcine viruses, retrovirus and rodent viruses.

We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.

The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.

Dry Ice

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C). After thawing, cells should be immediately transferred to the appropriate culture medium and maintained under recommended culture conditions.

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Avoid multiple freeze/thaw cycles

For research use only, not for diagnostic or therapeutic use.

All of our stable cell lines meet the highest quality standards and have been confirmed to be pathogen-free.