With the development of antibody discovery, bispecific antibody is a rapidly developing and expanding field. Several studies have reported that bispecific antibodies have better efficacy than monoclonal antibodies. However, there are still some problems in the development process, such as the multiple forms of bsAbs that affect the manufacture, Fc-mediated effector function and in vivo half-life. Meanwhile, selecting the right two targets to achieve synergistic therapeutic effects or higher efficacy is still more challenging than monoclonal antibodies combination. Therefore, the development of precise production of bifunctional mAb pair will be of great significance for the development of the antibody field.
Fig.1 Main design and applications of bispecific antibodies. (Antonarelli, et al., 2021)
Creative Biolabs succeed in providing Next™ bifunctional mAb pair development service enabling the production of two full-length antibody IgG molecules from a single host cell line. We use a molecular engineering approach to empower bifunctional mAb pair development that precisely controls the cognate pairing of antibody heavy chains (HCs) and light chains (HCs) during the assembly of two antibodies in a single host cell. Our service can be applied for the development of therapeutic antibody products that contain a mixture of two different antibodies in the field of oncology, immuno-oncology, inflammation, infectious diseases, and metabolic diseases.
Creative Biolabs provide a one-stop customized Next™ bifunctional mAb pair development service with long-term practical experience and novel technologies to ensure each project's desired outcome.
Fig.2 Our Next™ Bifunctional mAb Pair Development Service Workflow. (Creative Biolabs)
Multiple innovate antibody targets to meet customers’ needs
We have a wide range of available innovate antibody targets to develop bifunctional mAb pair, enabling the interdiction of multiple pathways by efficiently generating a single drug with more functions.
Highly experienced scientists to guarantee each customer's project executes smoothly.
Creative Biolabs consists of a experienced scientist team possessing a combined experience in the fields of antibody engineering, cell line development and analytics to guarantee each customer's project execute smoothly.
Customized services to empower bifunctional mAb pair development.
We provide proprietary bifunctional mAb pair development service enables the development of customized antibody combinations that possess the synergy of a two full-antibody combination to reduce the opportunity for tumor escape and drug resistance.
Q1: What are the advantages of mab pair development compared to bispecific antibody development?
A1: Bifunctional mab pairs are produced by the same host cell in a predefined ratio and can be purified using a conventional antibody manufacturing process. When addressing multiple targets, bifunctional mab pair products can offer more significant advantages and flexibility over bispecific antibodies.
Q2: What are the development challenges of mab pairs?
A2: Precisely controlling the cognate pairing of antibody heavy chains (HCs) and light chains (HCs) of antibodies in the production process is essential for the development of mab pairs. Creative Biolabs uses a molecular engineering approach to empower bifunctional mAb pair development that precisely controls the cognate pairing of antibody heavy chains (HCs) and light chains (HCs) during the assembly of two antibodies in a single host cell.
If you are interested in our Next™ Bifunctional mAb Pair Development Service, please contact us with no hesitation.
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