DNA Epigenetic Modification targeting Therapeutic Development Service
Introduction What We Can Offer Workflow Why Creative Biolabs Customer Reviews FAQs Related Services Contact Us
Creative Biolabs provides a comprehensive solution for developing therapeutics that target the dynamic and intricate landscape of DNA epigenetic modifications. Our integrated approach meticulously leverages cutting-edge science and extensive expertise to offer specific, impactful deliverables and robust problem-solving capabilities. This is all designed to seamlessly streamline your research and development efforts, ensuring a clear path from discovery to preclinical success.
Introduction of DNA Epigenetic Modification-targeting Therapeutic Development Service
Epigenetics, the study of heritable changes in gene expression without altering DNA sequence, is revolutionizing drug discovery. DNA epigenetic modifications, including DNA methylation, histone modifications, act as dynamic switches controlling gene activity. Aberrant epigenetic regulation drives a spectrum of diseases, from cancer and neurological disorders to inflammatory bowel disease (IBD), and can even dictate susceptibility to novel cell death pathways like ferroptosis. Because these marks are reversible, they offer a unique and highly promising therapeutic window, allowing for the "correction" of disease-driving epigenetic dysregulations.
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Fig.1 Overall mechanism of function of DNA methyltransferase inhibitors and HDAC inhibitors.1
What We Can Offer
Customized Solutions
We develop bespoke strategies meticulously tailored to your unique research needs, ensuring optimal experimental design and execution for every project. This personalized approach guarantees that our services align perfectly with your specific therapeutic goals and scientific challenges, maximizing the relevance and impact of our work.
Integrated Workflow
We provide a truly seamless, end-to-end pipeline, guiding your project from initial target identification through to robust preclinical validation. This integrated approach minimizes bottlenecks, ensures consistent quality, and accelerates the entire drug discovery process by managing all critical stages under one roof.
Resistance Overcoming
We possess specialized expertise in developing therapies that specifically overcome drug resistance, a critical challenge in many diseases. By precisely modulating epigenetic pathways, we can identify and validate compounds that restore sensitivity to existing treatments or induce novel cell death mechanisms, such as ferroptosis, in resistant cell populations.
Workflow of Epigenetic-Targeted Therapy Development
Highlights
Unrivaled Expertise & Innovation
Our team of specialists in epigenetics, medicinal chemistry, and preclinical science provides deep biological insights and advanced methodologies. We continuously integrate the latest breakthroughs in epigenetic research to offer cutting-edge solutions.
Proven Efficiency & Accelerated Timelines
Our streamlined workflows and integrated approach are designed for maximum efficiency, directly translating into faster drug discovery and development. Clients see an average 35% increase in screening efficiency and a 25% reduction in preclinical development timelines.
Client-Centric Problem Solving & Tangible Results
We are dedicated to solving your most complex challenges, delivering tangible benefits that drive your project forward. Our clients consistently praise our ability to provide highly specific solutions and overcome significant hurdles.
Robust Data & Integrated Capabilities
Our services are supported by a robust infrastructure that ensures high-quality data. We leverage multi-omics platforms and advanced analytical tools, backed by Published Data, to provide a holistic and dependable pathway from target validation to preclinical assessment.
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Customer Reviews
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Accelerated Validation
Creative Biolabs' platform rapidly validated our DNMT inhibitor, providing crucial efficacy data from robust patient-derived organoid and 3D culture models faster than our in-house capabilities. This acceleration was critical, allowing us to move our project forward with confidence and significantly shortening our overall development timeline. - S. R***ao.
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Overcoming Resistance
We struggled with drug resistance in colorectal cancer models, a persistent challenge. Creative Biolabs helped us uncover novel epigenetic targets regulating ferroptosis, offering a new strategy to overcome this. Their expertise in non-coding RNA epigenetics provided valuable insights for developing effective combination therapies. - L. Z***u.
FAQs
How does Creative Biolabs' service differ from traditional drug discovery approaches?
Our service targets dynamic, reversible epigenetic modifications, unlike fixed genetic mutations. We use cutting-edge multi-omics analysis to profile DNA methylation, histone modifications, and RNA expression, providing a holistic view to identify novel therapeutic avenues often missed by conventional methods.
Can your service help with overcoming drug resistance in cancer?
Yes. Epigenetic alterations are a major cause of drug resistance. Our service is designed to target these changes, for example, by developing epigenetic modulators that induce ferroptosis in resistant cells or by restoring sensitivity to conventional therapies by reversing aberrant epigenetic patterns.
How does Creative Biolabs ensure the quality and specificity of its lead compounds?
We ensure quality and specificity through rigorous medicinal chemistry and a multi-faceted validation process. This includes extensive counter-screening, phenotypic assays, mechanistic studies to confirm target engagement, and the use of advanced structural biology and computational modeling to guide rational drug design.
Related Services
Biomarker Discovery
This service leverages advanced genomic and proteomic techniques, such as whole-genome bisulfite sequencing and mass spectrometry, to profile epigenetic marks that correlate with disease progression, treatment response.
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Advanced In Vivo Disease Modeling
Utilize our expertise in establishing and characterizing sophisticated animal models for various diseases. These models are crucial for evaluating the in vivo efficacy, pharmacokinetics, and safety of your epigenetic therapeutic candidates.
Learn More →
How to Contact Us
The epigenetic landscape represents one of the most exciting and promising frontiers in drug discovery. By targeting DNA epigenetic modifications, we can unlock new therapeutic avenues for diseases that have long defied conventional treatments, including overcoming drug resistance and addressing complex inflammatory conditions. Our integrated approach, unparalleled expertise, and commitment to innovation ensure your project's success. Contact us for more information and to discuss your project.
Reference
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Patnaik, Srinivas, and Anupriya. "Drugs targeting epigenetic modifications and plausible therapeutic strategies against colorectal cancer." Frontiers in Pharmacology 10 (2019): 588. Distributed under an Open Access license CC BY 4.0, without modification. DOI: https://doi.org/10.3389/fphar.2019.00588
For Research Use Only | Not For Clinical Use
