PharmaOnco™ HEK293-Tg(Human TDO) Stable Cell Line, Single Clone (CAT#: ITS-0822-HMM211)

Creative Biolabs offers HEK293-Tg(Human TDO) stable cell line which the TDO gene stably expressed in HEK293 cells.

The HEK293-Tg(Human TDO) stable cell line is a genetically modified cell line derived from the human embryonic kidney (HEK) 293 cell line. In this stable cell line, the gene for human tryptophan 2,3-dioxygenase (TDO), an enzyme involved in tryptophan metabolism, has been stably integrated into the genome. This cell line can be used for studying the role of TDO in tryptophan metabolism, as well as for screening potential inhibitors or activators of TDO activity. It may also have applications in drug discovery and development, particularly in the field of cancer research where TDO has been implicated in promoting tumor growth and immune evasion.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

TDO

Human

HEK293

Genbank accession number NM_005651.1

The TDO gene, also known as tryptophan 2,3-dioxygenase, is an enzyme that catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan metabolism. This pathway is important in regulating immune responses, inflammation, and neurotransmitter synthesis. TDO is primarily expressed in the liver, where it plays a key role in regulating tryptophan levels in the body. By converting tryptophan to kynurenine, TDO helps to regulate the balance of this essential amino acid in the body. Mutations in the TDO gene have been associated with various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Research into the TDO gene and its role in these conditions is ongoing, with the hope of developing new treatment strategies targeting this pathway.