Human LRP5 Protein (Glu 644-Gln 1263) [Fc] (VAng-1900Lsx)
Human LRP5 protein, Mouse IgG2a Fc Tag, expressed in human 293 cells. (Uniprot ID: O75197-1)
Datasheet
Specifications
Source
HEK293 Cells.
Target
LRP5
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Tris with Glycine, Arginine and NaCl, pH 7.5.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
LRP5 (LDL Receptor Related Protein 5) is a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.
Alternative Names
LRP-5, LRP-5, LRP-7, LRP7, LR3
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