Recombinant 4-1BB / TNFRSF9 Protein (Leu 24-Gln 186) [Avi] [Fc] (VAng-0684Lsx)

Biotinylated Human 4-1BB, Avi tag, Fc Tag, was expressed in HEK 293 cells, with a molecular weight of 55-60 kDa. (Uniprot ID: NP_001552.2)

Datasheet

Specifications

Source

HEK293 Cells.

Target

4-1BB

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

PBS, pH 7.4.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

4-1BB is a member of the tumor necrosis factor (TNF) receptor family. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule. It can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, 4-1BB expression is found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of 4-1BB is its costimulatory activity for activated T cells. Crosslinking of 4-1BB enhances T cell proliferation, IL-2 secretion, survival and cytolytic activity.

Alternative Names

CD137; ILA; TNFRSF9; 4-1BB; CDw137