Recombinant B7-H5 Protein (Phe 33-Thr 192) [His] (VAng-1101Lsx)
Rhesus macaque B7-H5, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_001177807.1)
Applications
SDS-PAGE; WB; ELISA.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Introduction
B7-H5, also known as V-domain Ig suppressor of T cell activation (VISTA) is a type I transmembrane protein that functions as an immune checkpoint. VISTA is produced at high levels in tumor-infiltrating lymphocytes, such as myeloid-derived suppressor cells and regulatory T cells, and its blockade with an antibody results in delayed tumor growth in mouse models of melanoma and squamous cell carcinoma.
Alternative Names
B7-H5, SISP1, Gi24, VISTA
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