Recombinant Cynomolgus CTLA-4 Protein (aa 1-161) [Fc] (VAng-Cr3947)
Recombinant Cynomolgus CTLA-4 Protein (Met1-Asp161) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 40.4 kDa. (Accession ID: Q9BDC4)
Formulation
Lyophilized from sterile PBS, pH 7.4.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Introduction
CTLA-4 is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an off switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. CTLA4 is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells.
Alternative Names
ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12; cytotoxic T-lymphocyte associated protein 4
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