Recombinant E-Cadherin Protein (Gln 23-Pro 621) [Fc] (VAng-1474Lsx)

Human E-Cadherin, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: AAI41839)

Datasheet

Specifications

Source

HEK293 Cells.

Target

E-Cadherin

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

50 mM Tris, 100 mM Glycine, pH 7.5.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

E-Cadherin is a classical member of the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells, and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.E-cadherin (epithelial) is the most well-studied member of the cadherin family. It consists of 5 cadherin repeats (EC1-EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin.

Alternative Names

Cadherin-1, CDH1, CD324, E-cadherin, Arc-1, ECAD, LCAM, UVO