Recombinant Human B7-H4 Protein (aa 25-282, 26-258) [His] (VAng-3518Lsx)
Recombinant Human B7-H4 Protein, expressed in E. coli. (Uniprot ID: Q7Z7D3)
Datasheet
Specifications
Source
E. coli
Target
B7-H4
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
PBS, pH 7.4.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
B7-H4 is a protein that in humans is encoded by B7-H4 gene. B7-H4 belongs to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (CD28) on T lymphocytes. It inhibits T cell proliferation and cytokine production through ligation of an unknown receptor expressed by activated T cells. Notably, B7-H4 protein expression is observed in a high proportion of patients' tumors across a wide variety of malignancies. This high expression by tumors in combination with its low or absent protein expression in normal tissues makes B7-H4 an attractive immunotherapeutic target.
Alternative Names
B7H4; B7S1; B7X; B7h.5; PRO1291; VCTN1
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
