Recombinant Human TGFBR2 Protein (aa 1-159) [His] (VAng-Cr4051)
Recombinant Human TGFBR2 Protein (Met 1-Asp159) fused with a His tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 43.4 kDa. (Accession ID: NP_003233.4)
Datasheet
Specifications
Source
Human
Target
TGFBR2
Type
Tumor Antigens
Applications
ELISA.
Formulation
Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5.
Purity
> 97% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
TGFBR2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. TGF beta receptor 2 consists of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets (beta1-beta4, beta3-beta9).
Alternative Names
AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TGFR-2; TGFbeta-RII
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
