GITRL

GITRL is a protein that in humans is encoded by GITRL gene. GITR is a member of the tumor necrosis factor receptor (TNF-R) superfamily. This receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25+/CD4+ regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

CAT Product Name Source Product Overview Target Type Datasheet Size Price
VAng-Cr3844 Recombinant GITRL Protein (Glu74-Ser199) [His] Mammalian cells Recombinant GITRL Protein (Glu74-Ser199) fused with a His tag at N-terminus was expressed in Mammalian cells, with a molecular weight of 13.97 kDa. (Uniprot ID: Q9UNG2) GITRL Tumor Antigens Datasheet 100 µg Inquiry

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