Recombinant GITRL Protein (Glu74-Ser199) [His] (VAng-Cr3844)
Recombinant GITRL Protein (Glu74-Ser199) fused with a His tag at N-terminus was expressed in Mammalian cells, with a molecular weight of 13.97 kDa. (Uniprot ID: Q9UNG2)
Datasheet
Specifications
Source
Mammalian cells
Target
GITRL
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
GITRL is a protein that in humans is encoded by GITRL gene. GITR is a member of the tumor necrosis factor receptor (TNF-R) superfamily. This receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25+/CD4+ regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Alternative Names
AITR; CD357; TNFRSF18; GITR-D; tumor necrosis factor receptor superfamily member 18; TNF receptor superfamily member 18
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