4T1 In Vivo Metastasis Assay

This assay is to provide 4T1-based In Vivo Metastasis Assay to accelerate our client's oncology projects. The assay will be customized according to the specific requirements. Please contact our scientists to discuss more details.

4T1

Mouse

4T1 is a breast cancer cell line derived from the mammary gland tissue of a mouse BALB/c strain. 4T1 cells are epithelial and are resistant to 6-thioguanine. In preclinical research, 4T1 cells have been used to study breast cancer metastasis as they can metastasize to the lung, liver, lymph nodes, brain and bone.

Breast Cancer

Oncology

In Vivo Metastasis Assay

4T1-cell based In Vivo Metastasis Assay

Metastasis is defined as the formation of tumors that are discontinuous from the primary tumor. These secondary tumors can be at nearby or distant sites and can form, following the dissemination of cells via lymphatic, hematogenous, coelomic cavities, or epithelial cavities. Metastasis is not equivalent to invasion, adhesion, growth rate, susceptibility to immune cell killing, or any of the many steps in the metastatic cascade. These processes are necessary for successful colonization of the secondary sites, but they are not sufficient for a cell to be metastatic. Analysis of tumor growth and metastasis of human cancers requires the use of immunodeficient animals. Please contact us to learn more and offer the best-fit proposals for your program.

Oncology In Vivo Assays