AccuMetab™ Human CYP3A4 Enzyme, Catalytically Active with Cytochrome b5

CAT#: ITS-0426-YL64
Product Type: Recombinant Phase I Metabolizing Enzyme
Brand: AccuMetab
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Enhanced human CYP3A4 for high-activity Phase I metabolism profiling.
Brand
AccuMetab
Development Stage
ADME
ADME Research Domain
Metabolism
Background
Cytochrome b5 acts as an essential allosteric modulator and secondary electron donor that exponentially increases CYP3A4 catalytic turnover. This b5-enhanced system provides high-fidelity, high-activity in vitro data necessary for accurately simulating robust human hepatic clearance.
Key Features
Cytochrome b5 supplemented for max catalytic turnover; Generates robust metabolites for bound drug leads; The ultimate model for maximum hepatic clearance; Available in multiple reductase ratios
Applications
Enhanced Drug Metabolism Studies, MetID, DDI
Research Areas
ADME; Drug-Drug Interactions (DDI)
Species
Human
Expression System
Recombinant enzymes prepared from E. coli and co-expressed with NADPH CYP-reductase.
Physical Form
Liquid
Size
0.5 nmol; 1 nmol; 4 nmol; 10 mg
Storage
-80°C
Storage Comment
When stored at -80°C, our product remains stable and retains full functional activity for up to 10 years.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Our enzyme products are shipped at -80°C.
For Research Use Only | Not For Clinical Use
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