Creative Biolabs is committed to advancing therapeutic antibody and protein development through our specialized screening services. By leveraging our cutting-edge acetylcholine receptor panel screening service, we provide unparalleled insights into agonist and antagonist activities across various receptor targets.

Introduction to Acetylcholine Receptors

Acetylcholine receptors are critical components in the nervous system, playing pivotal roles in modulating synaptic transmission and neuronal communication. They are primarily divided into two types: nicotinic receptors (nAChRs), which function as ion channel receptors, and muscarinic receptors (mAChRs), which are G-protein-coupled receptors. Both types play essential roles in processes like muscle contraction, heart rate control, and cognitive function. Due to their significant role in numerous biological pathways, acetylcholine receptors are often targeted in the development of therapeutic drugs for neurological disorders, Alzheimer's disease, and even some muscular diseases.

• nAChRs: Particularly significant in neuromuscular junctions and known for their role in addiction and cognitive enhancement.
• mAChRs: Involved in central and peripheral nervous system functions and implicated in disorders like Parkinson's disease and schizophrenia.

Fig.1 The mAChRs and nAChRs regulate dopamine transmission.¹

Our Comprehensive Acetylcholine Receptor Panel Screening Service

Creative Biolabs has meticulously developed an extensive acetylcholine receptor panel screening service, specifically designed to address the complex needs of pharmaceutical research and development. This service is founded on years of scientific expertise and advancements in cellular assay development. We have generated a series of stable acetylcholine receptor overexpression cell lines, offering a dependable platform to assess both agonist and antagonist activities. Our panel encompasses a broad spectrum of AChR subtypes, including nAchRα1β1 and nAchRα4β2 for nAChRs, as well as M1 to M5 subtypes for mAChRs. This comprehensive coverage ensures that no potential target is missed during the screening process. By delivering highly reliable and reproducible screening assays, our service supports the characterization of prospective drug candidates, facilitating the optimization of their therapeutic efficacy and safety profiles.

Integration into Safety Panels and Drug Abuse Safety Panels

Recognizing the versatility and necessity of acetylcholine receptor targeting, we have also integrated our acetylcholine receptor panels into broader drug safety assessment frameworks. These panels now serve as essential components within our comprehensive safety evaluation protocols, including both general safety panels and specialized drug abuse safety panels. The drug abuse safety panels focus on evaluating compounds for their potential to cause dependence, while the safety panels ensure broader safety parameters are met, reducing the risk of adverse effects.

Why Choose Us?

• Comprehensive Receptor Coverage
  Our acetylcholine receptor panel includes a wide range of nAChR and mAChR subtypes, ensuring thorough evaluation of potential drug candidates and providing critical insights into agonist and antagonist activities.
• Reliable and Reproducible Assays
  With overexpression cell lines tailored for acetylcholine receptors, we provide dependable, reproducible results, facilitating the accurate assessment of drug efficacy and safety profiles.
• Integrated Safety Assessments
  Our acetylcholine receptor panels are seamlessly integrated into broader safety and drug abuse safety panels, ensuring that therapeutic candidates are tested for both efficacy and safety in complex biological systems.
• Expertise in Drug Development
  Creative Biolabs brings extensive expertise in acetylcholine receptor biology, offering advanced screening services supported by a team of professionals dedicated to optimizing therapeutic antibody and protein development.

Contact us today to learn more about how our acetylcholine receptor panel screening services can advance your research goals and transform the future of healthcare!

Reference

1. Threlfell, Sarah, and Stephanie Jane Cragg. "Dopamine signaling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons." Frontiers in systems neuroscience 5 (2011): 11. under Open Access license CC BY 4.0, without modification.

For Research Use Only | Not For Clinical Use