DBTRG-05MG In Vitro Metaphase Chromosome Analysis Assay

This assay is to provide DBTRG-05MG-based In Vitro Metaphase Chromosome Analysis Assay to accelerate our client's oncology projects. The assay will be customized according to the specific requirements. Please contact our scientists to discuss more details.

DBTRG-05MG

Human

The DBTRG-O5MG (Denver Brain Tumor Research Group 05) cell line was established from tissue from a patient with glioblastoma multiforme who had been treated with local brain irradiation and multidrug chemotherapy.

Brain Cancer

Oncology

In Vitro Metaphase Chromosome Analysis Assay

DBTRG-05MG-cell based In Vitro Metaphase Chromosome Analysis Assay

Metaphase chromosome analysis has become one of the main important tools in cancer genetics. As metaphase chromosomes are highly condensed and coiled, they are more appropriate for banding analysis and to subject for karyotyping.

Genome Alteration Assays

Aberrant or somatic mutations are more commonly found in the DNA of cancer cells compared to normal cells. There is an equilibrium that exists between DNA damage and repair in normal cells. However, in cancer cells these events are disturbed, resulting in mutations and genomic instability. Genomic instability in cancer cells causes chromosomal aberrations, microsatellite instability, aneuploidy and uncontrolled gene amplifications and genetic instability in cancer cells are mainly due to point mutations or chromosomal aberrations such as insertions, deletions and translocation, resulting in mutated proteins.