HCT-116 In Vitro Telomere Length Analysis Assay (Senescence)

This assay is to provide HCT-116-based In Vitro Telomere Length Analysis Assay (Senescence) to accelerate our client's oncology projects. The assay will be customized according to the specific requirements. Please contact our scientists to discuss more details.

HCT-116

Human

HCT 116 cell line was isolated from the colon of an adult male with colon cancer. It has a mutation in codon 13 of the ras proto-oncogene and can be used as a positive control for PCR assays of mutation in this codon.

Colorectal Adenocarcinoma; Colon Cancer

Oncology

In Vitro Telomere Length Analysis Assay (Senescence)

HCT-116-cell based In Vitro Telomere Length Analysis Assay (Senescence)

For the analysis of telomere length, terminal restriction fragment analysis technique has been the commonly used technique for a long time.

Cellular Senescence in Cancer Assays

Cell senescence is described as an irreversible physiological event of cell growth arrest, which is known to be caused by alterations of telomeres, oxidative stress, DNA damage and some oncogenes. Inhibition of the program of senescence is one of the main features of tumor cells and it has been reported that cancer cells can be induced to undergo senescence by chemo- and radiotherapies and genetic alterations. Telomeres help to prevent uncontrolled cell proliferation and the absence of telomeres results in aneuploidy and cell death.

Telomere Length Analysis Assay