HPB-ALL In Vitro S-nitrosylation Assay (Oxidative Stress)

This assay is to provide HPB-ALL-based In Vitro S-nitrosylation Assay (Oxidative Stress) to accelerate our client's oncology projects. The assay will be customized according to the specific requirements. Please contact our scientists to discuss more details.

HPB-ALL

Human

Established from the peripheral blood of a 14-year-old Japanese boy with ALL and thymoma at diagnosis in 1973.

Acute Lymphoblastic Leukemia; ALL

Oncology

In Vitro S-nitrosylation Assay (Oxidative Stress)

HPB-ALL-cell based In Vitro S-nitrosylation Assay (Oxidative Stress)

S-nitrosylation (attachment of NO to thiol side chains of the amino acid cysteine) and S-glutathionylation (attachment of GSH to thiol side chains of the amino acid cysteine) are two post-translational modification processes reported to increase with oxidative stress.

Oxidative Stress Assays

Disturbance between the production of reactive oxygen species (ROS), free radicals and antioxidant mechanisms is defined as the oxidative stress, or more precisely, it is an imbalance between the oxidant and antioxidant state in cells. This imbalance can cause harmful effects to cells and biomolecules, which ultimately causes adverse effects in the whole organism. Oxidative imbalance can target important proteinsand lipids in cells, which can increase the risk of developing a cancer. On the other hand, increased ROS production in cancer cells by certain cancer drugs can also arrest cancer cell cycle and cause senescence and apoptosis through oxidative stress.

Markers Thiobarbituric Acid Reactive Substances