MB49 In Vitro Anti-Tumor Efficacy Assay

This assay is to provide MB49-based In Vitro Anti-Tumor Efficacy Assay to accelerate our client's oncology projects. The assay will be customized according to the specific requirements. Please contact our scientists to discuss more details.

MB49

Mouse

MB49 cells are derived from C57BL/Icrf-a' mouse bladder epithelial cells that were transformed by a single 24-hour treatment with the chemical carcinogen 7, 12-dimethylbenz[a]anthracene (DMBA) on the second day of a long term primary culture. Transformed cells transplanted into syngeneic mice were shown to generate carcinomas. While of male origin, karyotype analyses indicate the loss of the Y chromosome in 100% of the cells analyzed. This abnormality is a frequent early event in human bladder cancer.

Bladder Cancer

Oncology

In Vitro Anti-Tumor Efficacy Assay

MB49-cell based In Vitro Anti-Tumor Efficacy Assay

Tumor-derived cell lines have been the mainstay for anti-cancer drug discovery, and the assessment of in vitro efficacy is a common method to evaluate the anti-cancer efficacy with various kinds of therapeutic candidates.

Oncology Efficacy Assays