Short Description
Quantifies ADH activity via NADH production.
Development Stage
Research-Grade Protein & Enzyme Assay Development
Description
The ModifiSite™ Alcohol Dehydrogenase Assay Kit measures ADH activity to assess liver metabolic capacity and drug-alcohol interactions. This kinetic assay is essential for researching alcohol dependence therapies and understanding the pharmacokinetics of ethanol metabolism. It validates the impact of drugs on the liver's detoxification pathways, helping to predict potential adverse effects.
Features
Kinetic measurement of NADH production; Assessing drug-alcohol interactions and liver metabolic capacity.
Process Relevance
ADME/Tox (Metabolic Stability)
Application Stage
ADME / DMPK
Applications
Studying alcohol metabolism and liver detoxification capacity.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Absorbance at 565 nm
Sample Type
Serum, citrate-plasma, urine, cell lysate, culture medium
Research Areas
Toxicology; Addiction Research
Datasheet