Short Description
Measures urokinase-type plasminogen activator activity.
Development Stage
Research-Grade Protein & Enzyme Assay Development
Description
The ModifiSite™ Urokinase Assay Kit employs chromogenic substrate cleavage to screen for inhibitors of uPA-mediated metastasis and invasion. This assay validates drugs targeting the plasminogen activation system, which is critical for tissue remodeling and cancer progression. It supports the discovery of anti-metastatic agents by quantifying the activity of this key extracellular protease.
Features
Chromogenic substrate cleavage; Screening inhibitors of uPA-mediated metastasis and invasion.
Process Relevance
Metastasis & Invasion Research
Application Stage
Lead Optimization
Applications
Cancer metastasis and tissue remodeling studies.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Fluorescence Detection (Ex 380 nm / Em 450 nm)
Sample Type
Serum, citrate-plasma, urine, cell lysate, culture medium
Research Areas
Oncology (Metastasis)
Datasheet