NCI-H522 In Vitro Telomere Length Analysis Assay (Senescence)

This assay is to provide NCI-H522-based In Vitro Telomere Length Analysis Assay (Senescence) to accelerate our client's oncology projects. The assay will be customized according to the specific requirements. Please contact our scientists to discuss more details.

NCI-H522

Human

This line was derived by A.F. Gazdar, H.K. Oie, J.D. Minna and associates from a lung cancer obtained from a patient prior to therapy.­

H522

Lung Cancer

Oncology

In Vitro Telomere Length Analysis Assay (Senescence)

For the analysis of telomere length, terminal restriction fragment anal ysis technique has been the commonly used technique for a long time.

Cellular Senescence in Cancer Assays

Cell senescence is described as an irreversible physiological event of cell growth arrest, which is known to be caused by alterations of telomeres, oxidative stress, DNA damage and some oncogenes. Inhibition of the program of senescence is one of the main features of tumor cells and it has been reported that cancer cells can be induced to undergo senescence by chemo- and radiotherapies and genetic alterations. Telomeres help to prevent uncontrolled cell proliferation and the absence of telomeres results in aneuploidy and cell death.

Telomere Length Analysis Assay