Nuclear receptors are pivotal in regulating gene expression and cellular responses, making them prime targets for therapeutic intervention. At Creative Biolabs, our nuclear reporter panel screening service offers a comprehensive solution to accelerate your research and development of therapeutic antibodies and proteins.

Nuclear Hormone Receptors

Nuclear hormone receptors (NHRs) are a superfamily of transcription factors that play crucial roles in regulating various physiological processes, including development, metabolism, and homeostasis. This family of receptors includes well-known members such as steroid hormone receptors, thyroid hormone receptors, retinoid X receptors, and certain vitamin receptors. Upon hormone binding, NHRs undergo conformational changes that enable them to interact with DNA segments, thereby modulating the transcriptional activity of target genes. Dysregulation of NHR function is often linked with a variety of diseases, such as cancer, metabolic disorders, and hormonal imbalances. Consequently, NHRs have emerged as crucial targets in drug discovery, particularly in addressing cancer, metabolic disorders, and endocrine diseases.

Fig.1 Human NHRs.¹

Cell-based Nuclear Reporter Screening Platform

Creative Biolabs offers a robust nuclear reporter panel screening service that covers a wide array of receptors to support diverse therapeutic developments. Our service leverages a cell-based reporter assay platform for evaluating the effects of potential drug candidates on NHR activity in a physiologically relevant cellular environment. Upon activation by NHRs, these reporter genes emit a detectable signal. By measuring changes in reporter gene expression, we can determine whether a candidate activates or inhibits specific NHRs, facilitating the identification of novel therapeutics tailored to target these crucial receptors.

Features of Our Nuclear Reporter Panel Screening Service

• Diverse Panel of Nuclear Receptors: We offer an extensive panel covering key NHRs, including but not limited to, the steroid hormone receptors (e.g., AR, GR, and MR), thyroid hormone receptors, and retinoid X receptors. This broad selection allows researchers to explore multiple targets and assess the specificity of their antibodies or proteins.
• Customizable Panel: We offer customizable panels to focus on specific NHRs, thus aligning the screening process with clients' precise research goals and therapeutic targets. Whether the objective is to explore a broad spectrum of receptors or focus on a particular NHR, our platform can be adapted to meet diverse research needs.
• High-Throughput Screening: Our platform is designed for high-throughput screening, allowing for the rapid evaluation of numerous drug candidates. This efficiency accelerates the drug discovery process, helping you to bring potential therapeutics to market faster.

Fig.2 List of NHRs established by Creative Biolabs.

Applications

• Cancer Therapeutic Screening
  NHRs are important targets in cancer treatment. Our nuclear reporter panel helps screen antibodies and proteins that affect NHR activity, supporting the discovery of cancer therapies by identifying compounds with specific receptor responses.
• Metabolic Disorder Research
  NHRs like PPARs and thyroid hormone receptors play key roles in metabolism. Our service helps test candidate drugs for their effects on these receptors, aiding the development of treatments for diabetes, obesity, and related conditions.
• Endocrine Disease Studies
  Steroid hormone receptors, including estrogen and androgen receptors, are central in hormonal regulation. Our screening platform supports research on receptor signaling, helping develop therapies for hormone-related disorders.
• Vitamin and Nutrient Pathway Analysis
  We offer panels for receptors related to vitamin D, retinoic acid, and other nutrients. These assays help study how compounds affect nutrient signaling, which is useful for immune health and chronic disease research.

Creative Biolabs invites you to leverage our cutting-edge nuclear reporter panel screening services to accelerate your therapeutic antibody and protein development projects. For more information on how Creative Biolabs assists you in achieving your research goals, please contact us today.

Reference

1. Kim, Eun Young, and Jae Man Lee. "Transcriptional regulation of hepatic autophagy by nuclear receptors." Cells 11.4 (2022): 620. Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only | Not For Clinical Use