Short Description
For efficient CTNNA1 staining, deploy this pre-prepared IHC kit, designed with all necessary reagents for a seamless antigen retrieval to coverslip procedure.
Description
Alpha catenin is a vital component of adherens junctions, linking E-cadherin-β-catenin complexes to the actin cytoskeleton. It also recruits additional proteins to form intercellular junctions. There are three forms of alpha catenin in humans: alpha-E, alpha-N, and alpha-T. These isoforms have similar amino-acid sequences but differ in tissue distribution. Alpha-E is found universally, alpha-N is specific to neurons, and alpha-T is primarily present in heart tissue. A reduction in alpha-E-catenin is commonly observed in various cancers, such as those of the breast, colon, stomach, esophagus, bladder, and liver, and is often correlated with tumor differentiation and metastasis.
Features
Ready to use
High Sensitivity Streptavidin (HSS) increases detection sensitivity
Suitable for tissue sections & cytospin preparations
Pre-diluted reagents minimize hands-on time
Optimizes mouse, rabbit, rat, goat, or sheep IgG primary antibody staining
Reactivity
Human, Mouse, Rat
Analytical Method
Immunohistochemistry
Datasheet
