OncoIHC™ HLA-E Ready-To-Use IHC Kit (CAT#: ITS-1122-ZP4980)

Facilitate HLA-E detection with this ready-to-use IHC solution, streamlining procedures from antigen retrieval through slide preparation.

Human major histocompatibility complex (MHC) antigens, also known as human leukocyte antigens (HLA), are encoded by genes on the short arm of chromosome 6 (6p21.3). The class I molecules, including HLA-A, B, and C, consist of a heavy (alpha) chain encoded by a class I gene and a β2-microglobulin chain. These molecules are involved in presenting foreign antigens to the immune system. HLA-E is a non-classical MHC class I molecule that is often overexpressed in tumors, transplanted tissues, and virus-infected cells. HLA-E interacts with the CD94/NKG2A, -B, and -C receptors on NK and T cells, functioning as an immune suppressor. This immune suppression enables tumors to evade immune surveillance.

Ready to use
High Sensitivity Streptavidin (HSS) increases detection sensitivity
Suitable for tissue sections & cytospin preparations
Pre-diluted reagents minimize hands-on time
Optimizes mouse, rabbit, rat, goat, or sheep IgG primary antibody staining

IHC

HLA-E

Human

Immunohistochemistry

FFPE tissue