Short Description
Enzymatic quantification of oxalate using oxalate oxidase.
Development Stage
Research-Grade Metabolic Assay Development
Description
The OXPHOSight™ Oxalate Assay Kit utilizes a robust enzymatic method to quantify oxalate levels, essential for assessing the risk of hyperoxaluria and calcium oxalate kidney stones. By enabling the precise measurement of urinary oxalate, this assay supports the development of therapeutics aimed at preventing nephrolithiasis. Its high-throughput compatibility makes it a valuable tool for large-scale renal safety profiling in pre-clinical toxicology.
Features
Enzyme-coupled reaction avoids harsh sample pretreatment; Adaptable to high-throughput screening for kidney stone prevention drugs.
Process Relevance
Nephrotoxicity Screening
Application Stage
Pre-clinical Safety
Applications
Analysis of urine oxalate levels for kidney stone risk assessment.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Absorbance at 595 nm
Sample Type
Urine, animal, and plant tissue samples
Research Areas
Nephrology (Kidney Stones); Urology
Datasheet