PC-9 In Vivo Metastasis Assay

This assay is to provide PC-9-based In Vivo Metastasis Assay to accelerate our client's oncology projects. The assay will be customized according to the specific requirements. Please contact our scientists to discuss more details.

PC-9

Human

PC-9 is lung adenocarcinoma cell line with a deletion in exon 19 of the EGFR gene that exhibits high sensitivity to TKIs. The PC-9G cell line (PC-9 cells resistant to gefitinib) was established by long-term exposure to gefitinib, and was shown to harbor the EGFR T790M mutation.

Lung Cancer

Oncology

In Vivo Metastasis Assay

Metastasis is defined as the formation of tumors that are discontinuous from the primary tumor. These secondary tumors can be at nearby or distant sites and can form, following the dissemination of cells via lymphatic, hematogenous, coelomic cavities, or epithelial cavities. Metastasis is not equivalent to invasion, adhesion, growth rate, susceptibility to immune cell killing, or any of the many steps in the metastatic cascade. These processes are necessary for successful colonization of the secondary sites, but they are not sufficient for a cell to be metastatic. Analysis of tumor growth and metastasis of human cancers requires the use of immunodeficient animals. Please contact us to learn more and offer the best-fit proposals for your program.

Oncology In Vivo Assays