Human Neuroblastoma Cell Line SK-N-MC

SK-N-MC cells represent a human neuroblastoma cell line that is extensively utilized in both neuroscience and cancer research. Below are some key points regarding SK-N-MC cells:

• Source: The SK-N-MC cell line originates from human neuroblastoma, which is a prevalent malignant tumor in children, generally arising from the sympathetic nervous system.
• Properties: These cells are known for their remarkable stability and uniformity, making them ideal for in vitro studies and the biological properties of neuronal cells.
• Uses: Given their neuronal features, SK-N-MC cells are widely employed to explore the processes of growth, differentiation, and apoptosis in nerve cells, as well as their reactions to various pharmaceuticals and compounds. They are also important in research related to oxidative stress, cellular signaling, and mechanisms of neuroprotection.
• Research Model: SK-N-MC cells are frequently used as a model system for assessing neurotoxicity and neuroprotective effects, allowing researchers to evaluate the protective properties of various substances on neuronal cells.
• Cultivation Conditions: Typically, SK-N-MC cells are cultured in a medium enriched with fetal bovine serum and antibiotics, and they are maintained at a 37°C environment.

Fig. 1 Urolithin A inhibits apoptosis in SK-N-MC cells subjected to oxidative stress.¹

SK-N-MC-based Proliferation Assay

Evaluating the effect of a compound in an SK-N-MC-based proliferation assay is essential for determining its potential as an anticancer drug, revealing the biological mechanisms of neuroblastoma, including the interactions between the compound and specific signaling pathways and cellular processes. It also helps determine its safety profile and identify any potential toxicities that may impact therapeutic applications. SK-N-MC-based proliferation assay uses staurosporine as the control inhibitor.

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Reference

1. Kim, K. B., Lee, S., & Kim, J. H. " Neuroprotective effects of urolithin A on H2O2-induced oxidative stress-mediated apoptosis in SK-N-MC cells." Nutrition Research and Practice 24.5 (2020): 3-11. Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only | Not For Clinical Use