Product Overview
TWS119 is a cell-permeable pyrrolopyrimidine compound that acts as a glycogen synthase kinase-3 beta (GSK3β) inhibitor. It induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs). GSK3 is a serine/threonine kinase that is a key inhibitor of the WNT pathway; therefore TWS119 functions as a WNT pathway activator. GSK-3β inhibition triggers autophagy.
Applications
Differentiation, Maintenance
Chemical Name
3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenol ditrifluoroacetate
Cell Type
Cancer Cells and Cell Lines, Pluripotent Stem Cells, T Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Area of Interest
Stem Cell Biology
Limitation
Restrictions for research use only. Intended for use by laboratory professionals.
Datasheet