Recombinant BTLA Protein (Lys 31-Ser 150) (VAng-1131Lsx)
Human BTLA is expressed in HEK 293 cells. (Uniprot ID: AAP44003.1)
Datasheet
Specifications
Source
HEK293 Cells.
Target
BTLA
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
PBS, pH 7.4.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
BTLA is a protein that in humans is encoded by BTLA gene. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a ligand for tumour necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.
Alternative Names
BTLA, CD272
Related Product
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